Sodium Picosulfate with Magnesium Citrate (SPMC) Plus Laxative Is a Good Alternative to Conventional Large Volume Polyethylene Glycol in Bowel Preparation: A Multicenter Randomized Single-Blinded Trial

被引：29

作者：

Kim, Hyun Gun ^{[1
]}

Huh, Kyu Chan ^{[2
]}

Koo, Hoon Sup ^{[2
]}

Kim, Seong-Eun ^{[3
]}

Kim, Jin-Oh

Kim, Tae Il ^{[4
]}

Kim, Hyun-Soo ^{[5
]}

Myung, Seung-Jae ^{[6
]}

Park, Dong Il ^{[7
]}

Shin, Jeong Eun ^{[8
]}

Yang, Dong-Hoon ^{[6
]}

Lee, Suck-Ho ^{[1
]}

Lee, Ji Sung ^{[9
]}

Lee, Chang Kyun ^{[10
]}

Chang, Dong Kyung ^{[11
]}

Joo, Young-Eun ^{[12
]}

Cha, Jae Myung ^{[10
]}

Hong, Sung Pil ^{[4
]}

Kim, Hyo Jong ^{[10
]}

机构：

[1] Soonchunhyang Univ, Coll Med, Dept Internal Med, Inst Digest Res, Seoul, South Korea

[2] Konyang Univ, Coll Med, Div Gastroenterol, Taejon 302718, South Korea

[3] Ewha Womans Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea

[5] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Div Gastroenterol, Wonju, South Korea

[6] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea

[7] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea

[8] Dankook Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Cheonan, South Korea

[9] Soonchunhynag Univ, Coll Med, Biostat Consulting Unit, Seoul, South Korea

[10] Kyung Hee Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea

[11] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med,Div Gastroenterol, Seoul, South Korea

[12] Chonnam Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Kwangju, South Korea

来源：

GUT AND LIVER | 2015年 / 9卷 / 04期

关键词：

Colonoscopy; Bowel preparation; Sodium picosulfate with magnesium citrate; Polyethylene glycols; COLONOSCOPY PREPARATION; MORNING COLONOSCOPY; DUAL-ACTION; EFFICACY; COLON; METAANALYSIS; TOLERABILITY; PICOSULPHATE; PHOSPHATE; CLEANSER;

D O I：

10.5009/gnl14010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (Pr) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

引用

页码：494 / 501

页数：8

共 30 条

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