Analgesic activity of acylated 2-benzoxazolinone derivatives

被引：19

作者：

Gökhan, N

Erdogan, H

Durlu, NT

Demirdamar, R

机构：

[1] Hacettepe Univ, Dept Pharmaceut Chem, Fac Pharm, Ankara, Turkey

[2] Hacettepe Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey

来源：

FARMACO | 1999年 / 54卷 / 1-2期

关键词：

2-benzoxazolinone; acylation; analgesic activity;

D O I：

10.1016/S0014-827X(98)00111-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ten new benzoxazolinone derivatives having a disubstituted benzoyl group at the six position of the ring were synthesized by reacting 2-benzoxazolinone with aromatic carboxylic acids in the presence of polyphosphoric acid. The structure of the compounds were elucidated by IR,H-1 NMR, MS and elemental analysis. Analgesic activity was evaluated by a modified Koster test. Seven compounds showed analgesic activities higher than that of acetylsalicylic acid. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：112 / 115

页数：4

共 29 条

[1] POTENTIAL ANTICANCER AND ANTIVIRAL AGENTS . SUBSTITUTED 3-[1'(2',3',4' - TRI-O-BENZOYL-BETA-D-RIBOPYRANOSYL)]-2-BENZOXAZOLINONES (1) [J].