Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A2A receptor agonist

被引:24
|
作者
Shukla, Manish [1 ]
Roy, Koustav [1 ]
Kaur, Charanjeet [2 ]
Nayak, Devasharma [1 ]
Mani, K. V. [1 ]
Shukla, Sangeeta [3 ]
Kapoor, Neeru [1 ]
机构
[1] Def Res & Dev Org, Def Inst Physiol & Allied Sci, Delhi, India
[2] All India Inst Med Sci, Dept Anat, Delhi, India
[3] Jiwaji Univ, Dept Zool, Gwalior, India
关键词
Noise; ABR; Adenosine A(2A); CGS; 21680; Neurogenesis; Memory; SPATIAL REFERENCE MEMORY; HIPPOCAMPAL NEUROGENESIS; SYNAPTIC-TRANSMISSION; A2A RECEPTOR; EXPOSURE; INJURY; ACTIVATION; EXPRESSION; CGS21680; SYSTEM;
D O I
10.1016/j.brainresbull.2019.02.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hearing loss and cognitive decline are commonly associated with aging and morbidity. Present clinical interest lies in whether peripheral hearing loss promotes cognitive decline and if prophylaxis with selective adenosine receptor agonist CGS21680 effectively mitigates the adverse effects. In the current study, male Sprague Dawley rats weighing 200-250 g m were randomly allocated into three groups: Group 1) rats exposed to 100 dB SPL white noise, 2 h a day for 15 consecutive days, 2) rats supplemented with an adenosine receptor agonist, CGS21680 at 100 mu g/kg/day prior to noise exposure and 3) unexposed control rats. Baseline hearing and cognition assessed by auditory brainstem response (ABR) and water maze respectively was undertaken for all the groups. Phalloidin stain and synaptic ribbons count in cochlea, and, Ki67, DCX and NeuN in hippocampus were observed by immunohistochemistry. It was inferred that noise exposed rats showed elevated thresholds of ABR and poorer performances in spatial working memory when compared with controls. On the contrary, CGS21680 administered group exhibited improved ABR and cognitive functions with shorter mean latency and path-length to reach the platform, significant reduction in the noise induced loss of synaptic ribbons count and increased number of Ki67 and doublecortin (DCX) positive cells compared to their noise exposed counterparts. Pharmacologic intervention with selective A(2A) receptor agonist CGS21680 provided adequate protection from noise by effectively maintaining hearing threshold levels, cell viability in cochlea and hippocampus & functional/intact reference memory.
引用
收藏
页码:47 / 57
页数:11
相关论文
共 50 条
  • [31] Attenuation of brain injury induced cognitive dysfunction and hyperlocomotion: Chronic administration enhanced the effects of adenosine A2A receptor antagonist
    Mullah, Saad
    Urmy, Jahanara
    Inaji, Motoki
    Nariai, Tadashi
    Ishibashi, Satoru
    Ohno, Kikuo
    BRAIN INJURY, 2014, 28 (5-6) : 744 - 744
  • [32] Effects of caffeine on coronary vasodilation and sinus tachycardia induced by Regadenoson, a novel adenosine A2A receptor agonist, in conscious dogs
    Zhao, G.
    Messina, E.
    Xu, X.
    Ochoa, M.
    Shryock, J.
    Belardinelli, L.
    Hintze, T. H.
    EUROPEAN HEART JOURNAL, 2006, 27 : 424 - 424
  • [33] Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist
    Satoh, Shinsuke
    Matsumura, Hitoshi
    Kanbayashi, Takashi
    Yoshida, Yasushi
    Urakami, Takahito
    Nakajima, Tomoko
    Kimura, Nobuko
    Nishino, Seiji
    Yoneda, Hiroshi
    BEHAVIOURAL BRAIN RESEARCH, 2006, 170 (02) : 277 - 286
  • [34] Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats
    Ryan K. Bachtell
    David W. Self
    Psychopharmacology, 2009, 206 : 469 - 478
  • [35] Caffeine and an adenosine A2A receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life
    Cognato, Giana P.
    Agostinho, Paula M.
    Hockemeyer, Joerg
    Mueller, Christa E.
    Souza, Diogo O.
    Cunha, Rodrigo A.
    JOURNAL OF NEUROCHEMISTRY, 2010, 112 (02) : 453 - 462
  • [36] New Agonist of Adenosine A2A Type Receptor Markedly Reduced Blood Pressure in Spontaneously Hypertensive Rats
    Sudo, Roberto T.
    Leal, Carla M.
    Leal, Daniella M.
    Tesch, Roberta
    Kummerle, Arthur E.
    Barreiro, Eliezer J.
    Fraga, Carlos A.
    Zapata-Sudo, Gisele
    HYPERTENSION, 2011, 58 (05) : E150 - E151
  • [37] Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat
    Fozard, JR
    Ellis, KM
    Dantas, MFV
    Tigani, B
    Mazzoni, L
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 438 (03) : 183 - 188
  • [38] Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats
    Hayes, Sarah H.
    Manohar, Senthilvelan
    Majumdar, Antara
    Allman, Brian L.
    Salvi, Richard
    HEARING RESEARCH, 2019, 379 : 43 - 51
  • [39] Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes
    Vuaden, Fernanda Cenci
    Baggio Savio, Luiz Eduardo
    Alves Bastos, Carolina Maria
    Bogo, Mauricio Reis
    Bonan, Carla Denise
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2011, 651 (1-3) : 212 - 217
  • [40] Effect of simultaneous application of adenosine A1 receptor agonist and A2A receptor antagonist on memory, inflammatory factors, and PSD-95 in lipopolysaccharide-induced memory impairment
    Ensandoust, Tahereh
    Khakpour-Taleghani, Behrooz
    Jafari, Adele
    Rostampour, Mohammad
    Rohampour, Kambiz
    Hedayati, Ch Mojtaba
    BEHAVIOURAL BRAIN RESEARCH, 2025, 476