Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p

被引：72

作者：

Arinami, T ^{[1
]}

Ohtsuki, T ^{[1
]}

Ishiguro, H ^{[1
]}

Ujike, H ^{[1
]}

Tanaka, Y ^{[1
]}

Morita, Y ^{[1
]}

Mineta, M ^{[1
]}

Takeichi, M ^{[1
]}

Yamada, S ^{[1
]}

Imamura, A ^{[1
]}

Ohara, K ^{[1
]}

Shibuya, H ^{[1
]}

Ohara, K ^{[1
]}

Suzuki, Y ^{[1
]}

Muratake, T ^{[1
]}

Kaneko, N ^{[1
]}

Someya, T ^{[1
]}

Inada, T ^{[1
]}

Yoshikawa, T ^{[1
]}

Toyota, T ^{[1
]}

Yamada, K ^{[1
]}

Kojima, T ^{[1
]}

Takahashi, S ^{[1
]}

Osamu, O ^{[1
]}

Shinkai, T ^{[1
]}

Nakamura, M ^{[1
]}

Fukuzako, H ^{[1
]}

Hashiguchi, T ^{[1
]}

Niwa, S ^{[1
]}

Ueno, T ^{[1
]}

Tachikawa, H ^{[1
]}

Hori, T ^{[1
]}

Asada, T ^{[1
]}

Nanko, S ^{[1
]}

Kunugi, H ^{[1
]}

Hashimoto, R ^{[1
]}

Ozaki, N ^{[1
]}

Iwata, N ^{[1
]}

Harano, M ^{[1
]}

Arai, H ^{[1
]}

Ohnuma, T ^{[1
]}

Kusumi, I ^{[1
]}

Koyama, T ^{[1
]}

Yoneda, H ^{[1
]}

Fukumaki, Y ^{[1
]}

Shibata, H ^{[1
]}

Kaneko, S ^{[1
]}

Higuchi, H ^{[1
]}

Yasui-Furukori, N ^{[1
]}

机构：

[1] Univ Tsukuba, Sch Comprehens Human Sci, Dept Med Genet, Tsukuba, Ibaraki 3058577, Japan

来源：

AMERICAN JOURNAL OF HUMAN GENETICS | 2005年 / 77卷 / 06期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1086/498122

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) is a multisite collaborative study group that was organized to create a national resource for affected sib pair (ASP) studies of schizophrenia in Japan. We used a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the Illumina BeadArray linkage mapping panel (version 4) comprising 5,861 SNPs, to perform a genomewide linkage analysis of JSSLG samples comprising 236 Japanese families with 268 nonindependent ASPs with schizophrenia. All subjects were Japanese. Among these families, 122 families comprised the same subjects analyzed with short tandem repeat markers. All the probands and their siblings, with the exception of seven siblings with schizoaffective disorder, had schizophrenia. After excluding SNPs with high linkage disequilibrium, we found significant evidence of linkage of schizophrenia to chromosome 1p21.2-1p13.2 (LOD = 3.39) and suggestive evidence of linkage to 14q11.2 (LOD = 2.87), 14q11.2- q13.2 (LOD = 2.33), and 20p12.1-p11.2 (LOD = 2.33). Although linkage to these regions has received little x attention, these regions are included in or partially overlap the 10 regions reported by Lewis et al. that passed the two aggregate criteria of a meta-analysis. Results of the present study-which, to our knowledge, is the first genomewide analysis of schizophrenia in ASPs of a single Asian ethnicity that is comparable to the analyses done of ASPs of European descent-indicate the existence of schizophrenia susceptibility loci that are common to different ethnic groups but that likely have different ethnicity-specific effects.

引用

页码：937 / 944

页数：8

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