Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

被引：576

作者：

van Es, Johan H. ^{[1
,2
]}

Sato, Toshiro ^{[1
,2
]}

van de Wetering, Marc ^{[1
,2
]}

Lyubimova, Anna ^{[3
]}

Nee, Annie Ng Yee ^{[4
]}

Gregorieff, Alex ^{[5
]}

Sasaki, Nobuo ^{[1
,2
]}

Zeinstra, Laura ^{[1
,2
]}

van den Born, Maaike ^{[1
,2
]}

Korving, Jeroen ^{[1
,2
]}

Martens, Anton C. M. ^{[6
,7
]}

Barker, Nick ^{[4
]}

van Oudenaarden, Alexander ^{[3
]}

Clevers, Hans ^{[1
,2
]}

机构：

[1] Hubrecht Inst Dev Biol & Stem Cell Res, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands

[3] MIT, Dept Phys & Biol, Cambridge, MA 02139 USA

[4] Inst Med Biol, Singapore, Singapore

[5] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[6] UMC Utrecht, Dept Immunol, NL-3508 AB Utrecht, Netherlands

[7] UMC Utrecht, Dept Cell Biol, NL-3508 AB Utrecht, Netherlands

来源：

NATURE CELL BIOLOGY | 2012年 / 14卷 / 10期

关键词：

MOUSE SMALL INTESTINE; ORIGIN; GENE; EXPRESSION; DIFFERENTIATION; POPULATION; COMMITMENT; RENEWAL; MARKER; MATH1;

D O I：

10.1038/ncb2581

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lgr5(+) intestinal stem cells generate enterocytes and secretory cells. Secretory lineage commitment requires Notch silencing. The Notch ligand Dill is expressed by a subset of immediate stem cell daughters. Lineage tracing in Dll1(GFP-ires-CreERT2) mice reveals that single Dll1(high) cells generate small, short-lived clones containing all four secretory cell types. Lineage specification thus occurs in immediate stem cell daughters through Notch lateral inhibition. Cultured Dll(1)high cells form long-lived organoids (mini-guts) on brief Wnt3A exposure. When Dll1(high) cells are genetically marked before tissue damage, stem cell tracing events occur. Thus, secretory progenitors exhibit plasticity by regaining stemness on damage.

引用

页码：1099 / +

页数：12

共 50 条

[41] OCT4 expression in human uterine myometrial stem/progenitor cells
Ono, M.
Kajitani, T.
Uchida, H.
Arase, T.
Oda, H.
Nishikawa-Uchida, S.
Masuda, H.
Nagashima, T.
Yoshimura, Y.
Maruyama, T.
HUMAN REPRODUCTION, 2010, 25 (08) : 2059 - 2067
[42] Transcriptome analysis of the response to thyroid hormone in Xenopus neural stem and progenitor cells
Cordero-Veliz, Camila
Larrain, Juan
Faunes, Fernando
DEVELOPMENTAL DYNAMICS, 2023, 252 (02) : 294 - 304
[43] A comparison of DNA damage induced by aflatoxin B1 in hepatocyte-like cells, their progenitor mesenchymal stem cells and CD34+ cells isolated from umbilical cord blood
Ghaderi, Masoumeh
Allameh, Abdolamir
Soleimani, Masoud
Rastegar, Hossein
Ahmadi-Ashtiani, Hamid Reza
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2011, 719 (1-2) : 14 - 20
[44] Nfatc1+ colonic stem cells contribute to regeneration upon colitis
Wang, Jianyang
Shang, Linkuo
Zhang, Jiahui
Yu, Zhengquan
Huang, Jiaqiang
Jin, Jing
Lv, Cong
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2022, 37 (04) : 734 - 740
[45] Enrichment of Mouse Spermatogonial Stem Cells by the Stem Cell Dye CDy1
Kanatsu-Shinohara, Mito
Morimoto, Hiroko
Shinohara, Takashi
BIOLOGY OF REPRODUCTION, 2016, 94 (01)
[46] Inhibition of Notch signaling reduces the number of surviving Dclk1+ reserve crypt epithelial stem cells following radiation injury
Qu, Dongfeng
May, Randal
Sureban, Sripathi M.
Weygant, Nathaniel
Chandrakesan, Parthasarathy
Ali, Naushad
Li, Linheng
Barrett, Terrence
Houchen, Courtney W.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2014, 306 (05): : G404 - G411
[47] Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice
Rothenberg, Michael E.
Nusse, Ysbrand
Kalisky, Tomer
Lee, John J.
Dalerba, Piero
Scheeren, Ferenc
Lobo, Neethan
Kulkarni, Subhash
Sim, Sopheak
Qian, Dalong
Beachy, Philip A.
Pasricha, Pankaj J.
Quake, Stephen R.
Clarke, Michael F.
GASTROENTEROLOGY, 2012, 142 (05) : 1195 - +
[48] Crypt region localization of intestinal stem cells in adults
Hugh James Freeman
World Journal of Gastroenterology, 2008, 14 (47) : 7160 - 7162
[49] Vascular Regeneration by Stem/Progenitor Cells
Xie, Yao
Fan, Ye
Xu, Qingbo
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (05) : e33 - e40
[50] Notch post-translationally regulates β-catenin protein in stem and progenitor cells
Kwon, Chulan
Cheng, Paul
King, Isabelle N.
Andersen, Peter
Shenje, Lincoln
Nigam, Vishal
Srivastava, Deepak
NATURE CELL BIOLOGY, 2011, 13 (10) : 1244 - U169

← 1 2 3 4 5 →