Preparation of 2,3-Disubstituted 5-Bromo-1H-pyrrolo[2,3-b]pyridine Framework by Fischer Cyclization

被引：8

作者：

Alekseyev, Roman S. ^{[1
]}

Amirova, Sabina R. ^{[2
]}

Terenin, Vladimir I. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Baku Branch, AZ-1144 Baku, Azerbaijan

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 20期

基金：

俄罗斯基础研究基金会;

关键词：

heterocycles; fused-ring systems; pyridines; pyrroles; cyclization; hydrazones; EFFICIENT SYNTHESIS; VARIOLIN-B; 7-AZAINDOLES; INHIBITORS; INDOLE; BROMINATION; REACTIVITY; AZAINDOLES; DISCOVERY; ALKALOIDS;

D O I：

10.1055/s-0034-1381040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of some hard-to-reach heterocycles containing 2,3-disubstituted 5-bromo-1H-pyrrolo[2,3-b]pyridine framework by Fis.her indole cyclization in polyphosphoric acid has been developed. A particularly valuable feature of this synthetic route is the possibility to build a 5-bromo-7-azaindole scaffold with alkyl or aryl substituents at positions 2 and 3 from available starting materials.

引用

页码：3169 / 3178

页数：10

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