Analysis of antibodies to surface epitopes of contactin-2 in multiple sclerosis

被引：22

作者：

Boronat, Anna ^{[1
]}

Sepulveda, Maria ^{[1
]}

Llufriu, Sara ^{[1
]}

Sabater, Lidia ^{[1
]}

Blanco, Yolanda ^{[1
]}

Gabilondo, Inigo ^{[1
]}

Sola, Nuria ^{[1
]}

Villoslada, Pablo ^{[1
]}

Dalmau, Josep ^{[2
,3
]}

Graus, Francesc ^{[1
]}

Saiz, Albert ^{[1
]}

机构：

[1] Univ Barcelona, Ctr Neuroimmunol, Serv Neurol, Hosp Clin, E-08036 Barcelona, Spain

[2] Univ Barcelona, Inst Catalana Recerca & Estudis Avancats ICREA, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Serv Neurol,Hosp Clin, E-08036 Barcelona, Spain

[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 244卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Multiple sclerosis; Contactin-2; Autoantibody; Cell-based assay; Magnetic resonance imaging; B-CELLS; ENCEPHALITIS; LESIONS;

D O I：

10.1016/j.jneuroim.2011.12.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Contactin-2 was recently identified as an autoantigen targeted by T-cells and autoantibodies in multiple sclerosis (MS). Here we analyzed the frequency of antibodies to contactin-2 (contactin-2-ab) by a cell-based assay in the serum from 105 MS patients and at least 5 years of follow-up (19 clinically isolated syndromes, 51 relapsing-remitting, 20 secondary-progressive, and 15 primary-progressive). Contactin-2-ab were detected in 4 (7.8%) relapsing-remitting patients. Clinical and magnetic resonance imaging characteristics were not significantly different from the rest of relapsing-remitting patients. In conclusion, contactin-2-ab are identified in a minority of MS patients but their presence is not associated with a particular clinical-radiological profile. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：103 / 106

页数：4

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