Controversies in small cell carcinoma of the head and neck: Prophylactic cranial irradiation (PCI) after primary complete initial remission

被引：3
作者：
De Felice, Francesca [1 ,2 ]
Lei, Mary [1 ]
Urbano, Teresa Guerrero [1 ]
机构：
[1] Guys & St Thomas NHS Fdn Trust, Dept Clin Oncol, London, England
[2] Univ Roma La Sapienza, Policlin Umberto I, Dept Radiotherapy, I-00185 Rome, Italy
来源：
CANCER TREATMENT REVIEWS | 2015年 / 41卷 / 08期
关键词：
Prophylactic cranial irradiation; Small cell carcinoma; Head and neck; Extrapulmonary; Remission; OF-THE-LITERATURE; LUNG-CANCER; NEUROENDOCRINE CARCINOMA; URINARY-BLADDER; INSTITUTIONAL EXPERIENCE; SINGLE INSTITUTION; BRAIN METASTASIS; CHEMOTHERAPY; LARYNX; RADIOTHERAPY;
D O I：
10.1016/j.ctrv.2015.05.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Small cell carcinoma of head and neck region (SmCCHN) represents a rare entity and its management remains a significant clinical challenge. Complete initial response to primary therapy poses a difficult and controversial scenario for radiation oncologists. Prophylactic cranial irradiation (PCI) has long been established in the management of small cell lung cancer; however, its role in SmCCHN is still called into question. The rationale behind PCI lies in the eradication of possible micro-metastatic brain disease, which is often documented in this type of cancer. No randomized trials on this topic are available. This review, based on 20 retrospective studies, addresses the controversies in the use of PCI in SmCCHN management. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：725 / 728
页数：4
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