Localization of PDK-1 mRNA in the brain of developing and adult rats

被引：4
作者：
Yoshida, S [1 ]
Sakagami, H
Owada, Y
Kokubun, S
Kondo, H
机构：
[1] Tohoku Univ, Grad Sch Med Sci, Div Histol, Dept Cell Biol, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Sendai, Miyagi 9808575, Japan
来源：
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1999年 / 187卷 / 03期
关键词：
3-phosphoinositide-dependent protein kinase-1; rat; brain; development; in situ hybridization;
D O I：
10.1620/tjem.187.249
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gene expression for 3-phosphoinositide-dependent protein kinase-1 (PDR-1) in developing and adult rat brains was examined by in situ hybridization histochemistry. In embryonic days, the mRNA mas evident throughout the entire neuraxis. The expression remained evident throughout the entire gray matters until postnatal day 7, and thereafter it decreased overall in the mantle and ventricular zones except for the cerebellar Purkinje and granule cell layers, the olfactory and hippocampal neuronal layers. The pattern of this gene expression is similar to those of for protein kinase B and class I phosphoinositide 3-kinases.
引用
收藏
页码：249 / 255
页数：7
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