Questioning the predictive validity of the amphetamine-induced hyperactivity model for screening mood stabilizing drugs

被引:9
作者
Lan, Anat [1 ,2 ]
Einat, Haim [1 ,3 ,4 ]
机构
[1] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Rabenu Yeruham 14, Tel Aviv, Israel
[2] Open Univ, Tel Aviv, Israel
[3] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Beer Sheva, Israel
[4] Univ Minnesota, Sch Pharm, Minneapolis, MN 55455 USA
关键词
Affective disorders; Animal models; Bipolar disorder; Validity; Psychostimulants; Screening model; CHRONIC LITHIUM TREATMENT; BLACK SWISS MICE; ANIMAL-MODELS; BIPOLAR DISORDER; BEHAVIOR; STRAIN; SENSITIZATION; CARBAMAZEPINE; VALIDATION; CARBONATE;
D O I
10.1016/j.bbr.2019.01.006
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Animal models are critical for the study of disease mechanisms and the screening of potential novel treatments. In the context of bipolar disorder, amphetamine-induced hyperactivity (AIH) is a frequently used screening model for antimanic effects. Yet, the utility of screening models depends on their predictive (or pharmacological) validity and it is expected that such models will respond to effective treatments. Lithium is the prototypic mood stabilizer but previous data regarding the effects of lithium in the AIH model are not clear and most data comes from studies using acute lithium administration that is not relevant to the therapeutic regimen in patients. To evaluate the pharmacological validity of AIH as a model for mania-like behavior we tested the interaction between chronic oral administration of lithium and amphetamine in ICR (CD-1 (R)) mice and in black Swiss mice. We conducted 4 different experiments where chronic lithium was followed by an acute injection of amphetamine and one experiment where chronic amphetamine was combined with chronic lithium. The results show that amphetamine result in hyperactivity (experiments 1-4) and that lithium has no effects. Moreover, chronic amphetamine (experiment 5) result in sensitization that is not attenuated by lithium. The results clearly show that the predictive validity of the AIH model in ICR or black Swiss mice is problematic and possibly cast doubt on the utilization of the AIH as a screening model for novel mood stabilizers in other strains of mice.
引用
收藏
页码:109 / 113
页数:5
相关论文
共 47 条
[1]   Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients [J].
Anand, A ;
Verhoeff, P ;
Seneca, N ;
Zoghbi, SS ;
Seibyl, JP ;
Charney, DS ;
Innis, RB .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (07) :1108-1114
[2]   DIFFERENTIAL-EFFECTS OF CLASSICAL AND NEWER ANTIPSYCHOTICS ON THE HYPERMOTILITY INDUCED BY 2 DOSE LEVELS OF D-AMPHETAMINE [J].
ARNT, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 283 (1-3) :55-62
[3]   Lithium and valproate attenuate dextroamphetamine-induced changes in brain activation [J].
Bell, EC ;
Willson, MC ;
Wilman, AH ;
Dave, S ;
Asghar, SJ ;
Silverstone, PH .
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2005, 20 (02) :87-96
[4]  
Belmaker a, 2007, BIPOLAR DISORDERS BA, V2nd
[5]   Medical progress: Bipolar disorder [J].
Belmaker, RH .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (05) :476-486
[6]   Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression [J].
Belzung, Catherine ;
Lemoine, Mael .
BIOLOGY OF MOOD & ANXIETY DISORDERS, 2011, 1 (01)
[7]   EFFECT OF LITHIUM ON AMPHETAMINE-INDUCED LOCOMOTOR STIMULATION [J].
BERGGREN, U ;
TALLSTEDT, L ;
AHLENIUS, S ;
ENGEL, J .
PSYCHOPHARMACOLOGY, 1978, 59 (01) :41-45
[8]   LITHIUM PREVENTION OF AMPHETAMINE-INDUCED MANIC EXCITEMENT AND OF RESERPINE-INDUCED DEPRESSION IN MICE - POSSIBLE ROLE OF 2-PHENYLETHYLAMINE [J].
BORISON, RL ;
SABELLI, HC ;
MAPLE, PJ ;
HAVDALA, HS ;
DIAMOND, BI .
PSYCHOPHARMACOLOGY, 1978, 59 (03) :259-262
[9]   Antidepressant-like responses to lithium in genetically diverse mouse strains [J].
Can, A. ;
Blackwell, R. A. ;
Piantadosi, S. C. ;
Dao, D. T. ;
O'Donnell, K. C. ;
Gould, T. D. .
GENES BRAIN AND BEHAVIOR, 2011, 10 (04) :434-443
[10]   EFFECTS OF LITHIUM ON AN AMPHETAMINE ANIMAL-MODEL OF BIPOLAR DISORDER [J].
CAPPELIEZ, P ;
MOORE, E .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1990, 14 (03) :347-358