In Vivo Selection of Rifamycin-Resistant Clostridium difficile during Rifaximin Therapy

被引：28
作者：
Carman, Robert J. [1 ]
Boone, James H. [1 ]
Grover, Harish [2 ]
Wickham, Kimberly N. [1 ]
Chen, Li [1 ]
机构：
[1] TechLab Inc, Blacksburg, VA USA
[2] Carilion Clin Gastroenterol, Christiansburg, VA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 11期
关键词：
RIFAMPIN RESISTANCE; GENE;
D O I：
10.1128/AAC.00974-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.
引用
收藏
页码：6019 / 6020
页数：2
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