In Vivo Selection of Rifamycin-Resistant Clostridium difficile during Rifaximin Therapy

被引：28

作者：

Carman, Robert J. ^{[1
]}

Boone, James H. ^{[1
]}

Grover, Harish ^{[2
]}

Wickham, Kimberly N. ^{[1
]}

Chen, Li ^{[1
]}

机构：

[1] TechLab Inc, Blacksburg, VA USA

[2] Carilion Clin Gastroenterol, Christiansburg, VA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 11期

关键词：

RIFAMPIN RESISTANCE; GENE;

D O I：

10.1128/AAC.00974-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the selection of Clostridium difficile resistant to the rifamycin class of antibiotics in a patient within 32 h of receiving rifaximin for the treatment of recurrent C. difficile diarrhea. Resistance was associated with single nucleotide substitutions within rpoB.

引用

收藏

页码：6019 / 6020

页数：2

相关论文

共 9 条

[1] Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus [J].

Aubry-Damon, H ;

Soussy, CJ ;

Courvalin, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (10) :2590-2594

[2] High Frequency of Rifampin Resistance Identified in an Epidemic Clostridium difficile Clone from a Large Teaching Hospital [J].

Curry, Scott R. ;

Marsh, Jane W. ;

Shutt, Kathleen A. ;

Muto, Carlene A. ;

O'Leary, Mary M. ;

Saul, Melissa I. ;

Pasculle, A. William ;

Harrison, Lee H. .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (04) :425-429

[3] A randomized, double-blind, placebo-controlled pilot study to assess the ability of rifaximin to prevent recurrent diarrhoea in patients with Clostridium difficile infection [J].

Garey, Kevin W. ;

Ghantoji, Shashank S. ;

Shah, Dhara N. ;

Habib, Musarat ;

Arora, Vaneet ;

Jiang, Zhi-Dong ;

DuPont, Herbert L. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (12) :2850-2855

[4] Rifaximin Redux: Treatment of recurrent Clostridium difficile infections with Rifaximin immediately post-vancomycin treatment [J].

Johnson, Stuart ;

Schriever, Christopher ;

Patel, Ursula ;

Patel, Toral ;

Hecht, David W. ;

Gerding, Dale N. .

ANAEROBE, 2009, 15 (06) :290-291

[5] Multiplex PCR targeting tpi (triose phosphate isomerase), tcdA (Toxin a), and tcdB (Toxin b) genes for toxigenic culture of Clostridium difficile [J].

Lemee, L ;

Dhalluin, A ;

Testelin, S ;

Mattrat, MA ;

Maillard, K ;

Lemeland, JF ;

Pons, JL .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (12) :5710-5714

[6] In Vivo Selection of Moxifloxacin-Resistant Clostridium difficile [J].

Mena, Ana ;

Riera, Elena ;

Lopez-Causape, Carla ;

Weber, Irene ;

Perez, Jose L. ;

Oliver, Antonio .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (05) :2788-2789

[7] Divergent Rifamycin Susceptibilities of Clostridium difficile Strains in Canada and Italy and Predictive Accuracy of Rifampin Etest for Rifamycin Resistance [J].

Miller, Mark A. ;

Blanchette, Ruth ;

Spigaglia, Patrizia ;

Barbanti, Fabrizio ;

Mastrantonio, Paola .

JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (12) :4319-4321

[8] Rifampin and rifaximin resistance in clinical isolates of Clostfdium diicile [J].

O'Connor, Jennifer R. ;

Galang, Minerva A. ;

Sambol, Susan P. ;

Hecht, David W. ;

Vedantam, Gayatri ;

Gerding, Dale N. ;

Johnson, Stuart .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (08) :2813-2817

[9] PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes [J].

Stubbs, SLJ ;

Brazier, JS ;

O'Neill, GL ;

Duerden, BI .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (02) :461-463