Inhibitory effect of fluvastatin on ileal ulcer formation in rats induced by nonsteroidal antiinflammatory drug

被引：10

作者：

Hagiwara, Mari ^{[1
]}

Kataoka, Keiko ^{[1
]}

Arimochi, Hideki ^{[1
]}

Kuwahara, Tomomi ^{[1
]}

Nakayama, Haruyuki ^{[1
]}

Ohnishi, Yoshinari ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch Med, Dept Mol Bacteriol, Tokushima 7708503, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 07期

关键词：

Ileal ulcer; Fluvastatin; HMG-CoA reductase inhibitors; Nonsteroidal antiinflammatory drug;

D O I：

10.3748/wjg.v11.i7.1040

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: Nonsteroidal anti-inflammatory drugs (NSAIDs) cause gastrointestinal damage as one of their side effects in humans and experimental animals. Lipid peroxidation plays an important role in NSAID-induced ulceration. The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats. METHODS: The effects of three HMG-CoA reductase inhibitors, fluvastatin, pravastatin and atorvastatin on ileal ulcer formation in 5-bromo-2-(4-fluorophenyl)-3-(4-methylsulfonylphenyl) thiophene (BFMeT)-treated rats were examined. Antioxidative activity of the inhibitors was measured by a redox-linked colorimetric method. RESULTS: Fluvastatin, which was reported to have antioxidative activity, repressed the ileal ulcer formation in rats treated with BFMeT an NSAIDs. However, the other HMG-CoA reductase inhibitors (pravastatin and atorvastatin) did not repress the ileal ulcer formation. Among these HMG-CoA reductase inhibitors, fluvastatin showed a significantly stronger reducing power than the others (pravastatin, atorvastatin). CONCLUSION: Fluvastatin having the antioxidaitive activity suppresses ulcer formation in rats induced by NSAIDs. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：1040 / 1043

页数：4

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