Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans

被引：12

作者：

Neumann, Serina A. ^{[1
]}

Linder, Katherine J. ^{[1
]}

Muldoon, Matthew F. ^{[2
]}

Sutton-Tyrrell, Kimberly

Kline, Christopher ^{[3
]}

Shrader, Catherine J. ^{[1
]}

Lawrence, Elizabeth C. ^{[3
]}

Ferrell, Robert E. ^{[3
]}

Manuck, Stephen B. ^{[4
]}

机构：

[1] Eastern Virginia Med Sch, Dept Psychiat & Behav Sci, Norfolk, VA 23501 USA

[2] Univ Pittsburgh, Sch Med, Ctr Clin Pharmacol, Pittsburgh, PA USA

[3] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

来源：

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING | 2012年 / 28卷 / 02期

关键词：

Atherosclerosis; Intima-media thickness; Plaque; Cholinergic function; Choline transport; Acetylcholine; HEART-RATE-VARIABILITY; HERITABILITY; THICKNESS; SYSTEM; DEPRESSION; INSULIN; IMPACT; RISK;

D O I：

10.1007/s10554-011-9831-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a heritable trait with little known about specific genetic influences on preclinical measures of plaque formation. Based on relations of parasympathetic-cholinergic function to atherosclerosis and to a choline transporter gene [CHT1 (G/T)] polymorphism, we investigated whether the same allelic variant predicts variation in carotid intima-media thickness (IMT) and plaque formation. Carotid IMT and plaque occurrence as well as genotyping for the CHT1 (G/T) variant were measured in a sample (N = 264) of generally healthy adults (age 30-55) of European ancestry. CHT1 GG homozygotes had greater IMT (P < 0.005) and plaque occurrence (P < 0.020) than T allele carriers. This is the first study showing polymorphic variation in the CHT1 gene to predict early, subclinical measures of carotid atherosclerosis which may aid in understanding cholinergic-vagal processes potentially underlying atherosclerotic risk.

引用

页码：243 / 250

页数：8

共 2 条

[1] Polymorphic variation in choline transporter gene (CHT1) is associated with early, subclinical measures of carotid atherosclerosis in humans
Serina A. Neumann
Katherine J. Linder
Matthew F. Muldoon
Kimberly Sutton-Tyrrell
Christopher Kline
Catherine J. Shrader
Elizabeth C. Lawrence
Robert E. Ferrell
Stephen B. Manuck
The International Journal of Cardiovascular Imaging, 2012, 28 : 243 - 250
[2] Heart rate variability is associated with polymorphic variation in the choline transporter gene
Neumann, SA
Lawrence, EC
Jennings, JR
Ferrell, RE
Manuck, SB
PSYCHOSOMATIC MEDICINE, 2005, 67 (02): : 168 - 171

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