High Prevalence of Cardiometabolic Comorbidities Among Children and Adolescents With Severe Obesity From a Large Metropolitan Centre (Hangzhou, China)

被引:7
|
作者
Wang, Jinling [1 ]
Lin, Hu [1 ]
Chiavaroli, Valentina [2 ,3 ]
Jin, Binghan [1 ]
Yuan, Jinna [1 ]
Huang, Ke [1 ]
Wu, Wei [1 ]
Dong, Guanping [1 ]
Derraik, Jose G. B. [1 ,3 ,4 ,5 ]
Fu, Junfen [1 ]
机构
[1] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Endocrinol,Sch Med, Hangzhou, Peoples R China
[2] Pescara Publ Hosp, Neonatal Intens Care Unit, Pescara, Italy
[3] Univ Auckland, Liggins Inst, Auckland, New Zealand
[4] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden
[5] Chiang Mai Univ, Res Inst Hlth Sci, Environm & Occupat Hlth Sci & Noncommunicable Dis, Chiang Mai, Thailand
来源
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金
中国国家自然科学基金;
关键词
abnormal liver function; acanthosis nigricans; blood pressure; China; glucose metabolism; hypertension; insulin sensitivity; NAFLD; ELEVATED BLOOD-PRESSURE; CHILDHOOD OBESITY; INSULIN SENSITIVITY; METABOLIC SYNDROME; INCREASED RISK; EPIDEMIOLOGY; HYPERTENSION; HEALTH;
D O I
10.3389/fendo.2022.807380
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
ObjectiveThis study aimed to describe the clinical characteristics of children and adolescents with obesity, and the prevalence of cardiometabolic comorbidities over 10 years in this population from a large metropolitan centre in China. MethodsThis was a cross-sectional study (2008-2017) of patients aged <18 years with obesity [body mass index (BMI) >= 95th percentile for age and sex] enrolled at the Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine (Hangzhou, Zhejiang Province). Clinical assessments included anthropometry, blood pressure, liver ultrasound, lipid profile, oral glucose tolerance test, and uric acid. For examination of outcomes, our study cohort was stratified by sex and age bands (<10 vs. >= 10 years), with the study period also split into two strata (2008-2012 and 2013-2017). ResultsA total of 2,916 patients (1,954 boys and 962 girls) were assessed at a mean age of 10.5 years. Patients almost invariably presented severe obesity (median BMI SDS = 2.98; Q1 = 2.60, Q3 = 3.39). Obesity-related comorbidities were common among boys and girls, including type 2 diabetes mellitus (2.6% and 3.6%, respectively), abnormal glycaemia (33.6% and 35.5%, respectively), hypertension (33.9% and 32.0%, respectively), dyslipidaemia (35.2% and 39.6%, respectively), hyperuricaemia (16.2% and 8.3%, respectively), acanthosis nigricans (71.9% and 64.0%, respectively), abnormal liver function (66.9% and 47.0%, respectively), and non-alcoholic fatty liver disease (NAFLD) (63.8% and 45.1%, respectively); 38.7% of boys and 44.4% of girls aged >= 10 years had metabolic syndrome. Notably, the incidence of many cardiometabolic comorbidities was in 2013-2017 compared to 2008-2012. For example, rates of hypertension among boys aged <10 years and aged >= 10 years rose from 28.4% and 26.5% to 48.0% and 35.8%, respectively, and in girls from 20.3% and 20.8% to 41.7% and 39.6%, respectively. In 2013-2017, 9.5% of girls in the older group had metabolic syndrome compared to 2.2% in 2008-2013. ConclusionsWe observed a high incidence of obesity-related cardiometabolic comorbidities among Chinese children and adolescents with severe obesity over 10 years. It was particularly concerning that rates of several comorbidities rose markedly over the study period, highlighting the need to address the obesity epidemic early in life (in China and elsewhere) to prevent the development of obesity-related comorbidities and, subsequently, of overt disease.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] High prevalence of undiagnosed comorbidities among adolescents with obesity
    Leong, Karen S. W.
    Jayasinghe, Thilini N.
    Wilson, Brooke C.
    Derraik, Jose G. B.
    Albert, Benjamin B.
    Chiavaroli, Valentina
    Svirskis, Darren M.
    Beck, Kathryn L.
    Conlon, Cathryn A.
    Jiang, Yannan
    Schierding, William
    Vatanen, Tommi
    Holland, David J.
    O'Sullivan, Justin M.
    Cutfield, Wayne S.
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [2] High prevalence of undiagnosed comorbidities among adolescents with obesity
    Karen S. W. Leong
    Thilini N. Jayasinghe
    Brooke C. Wilson
    José G. B. Derraik
    Benjamin B. Albert
    Valentina Chiavaroli
    Darren M. Svirskis
    Kathryn L. Beck
    Cathryn A. Conlon
    Yannan Jiang
    William Schierding
    Tommi Vatanen
    David J. Holland
    Justin M. O’Sullivan
    Wayne S. Cutfield
    Scientific Reports, 10
  • [3] High prevalence of undiagnosed metabolic dysfunction among children and adolescents with obesity in China
    Wang, Jinling
    Fu, Junfen
    HORMONE RESEARCH IN PAEDIATRICS, 2021, 94 (SUPPL 1): : 83 - 83
  • [4] Prevalence and Trends of Severe Obesity Among US Children and Adolescents
    Skelton, Joseph A.
    Cook, Stephen R.
    Auinger, Peggy
    Klein, Jonathan D.
    Barlow, Sarah E.
    ACADEMIC PEDIATRICS, 2009, 9 (05) : 322 - 329
  • [5] The prevalence of severe obesity and related comorbidities has increased during the last decade among children and adolescents referred for evaluation at the obesity clinic
    Velfer, Yael Avnieli
    Phillip, Moshe
    Shalitin, Shlomit
    HORMONE RESEARCH IN PAEDIATRICS, 2019, 91 : 412 - 412
  • [6] Prevalence of severe obesity and its association with elevated blood pressure among children and adolescents in Shandong, China
    Zhang, Ying-Xiu
    Wang, Shu-Rong
    Li, Su-Yun
    BLOOD PRESSURE MONITORING, 2017, 22 (06) : 345 - 350
  • [7] Prevalence of overweight and obesity among children and adolescents is associated with urbanization in Shandong, China
    Zhang, Ying-xiu
    Zhao, Jin-shan
    Chu, Zun-hua
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 176 (03) : 1212 - 1213
  • [8] Prevalence and Trends in Obesity among China's Children and Adolescents, 1985-2010
    Sun, Hongpeng
    Ma, Yana
    Han, Di
    Pan, Chen-Wei
    Xu, Yong
    PLOS ONE, 2014, 9 (08):
  • [9] Synchronous prevalence of obesity and elevated blood pressure among children and adolescents in Shandong, China
    Zhang, Ying-xiu
    Zhou, Jing-yang
    Zhao, Jin-shan
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2014, 174 (02) : 462 - 463
  • [10] Prevalence of overweight and obesity and their associations with blood pressure among children and adolescents in Shandong, China
    Dong, Jing
    Guo, Xiao-Lei
    Lu, Zi-Long
    Cai, Xiao-Ning
    Wang, Hui-Cheng
    Zhang, Ji-Yu
    Yan, Liu-Xia
    Xu, Ai-Qiang
    BMC PUBLIC HEALTH, 2014, 14