MODIFICATION OF THE PICTET-SPENGLER REACTION IN THE SYNTHESIS OF FUSED 2,3-BENZODIAZOCINES

被引：2
|
作者：
Tolkunov, A. S. [1 ]
Baumer, V. N. [2 ]
Palamarchuk, G. V. [2 ]
Shishkin, O. V. [2 ,3 ]
Mazepa, A. V. [4 ]
Tolkunov, S. V. [1 ]
Bogza, S. L. [1 ]
机构：
[1] Natl Acad Sci Ukraine, LM Litvinenko Inst Phys Organ Chem & Coal Chem, UA-83114 Donetsk, Ukraine
[2] Natl Acad Sci Ukraine, Inst Single Crystals, Res Branch Chem Funct Mat, UA-61001 Kharkov, Ukraine
[3] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine
[4] Natl Acad Sci Ukraine, AV Bogatsky Physicochem Inst, UA-65080 Odessa, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 08期
关键词：
3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one; fused diazocines; hydrochloric acid; tetrahydroquinazolino[3,2-c][2,3]benzodiazocin-15-ones; trifluoroacetic acid; cyclization; Pictet-Spengler reaction; N-NITRENES; INTRAMOLECULAR REACTIONS; DERIVATIVES; ALKENES;
D O I：
10.1007/s10593-011-0867-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new strategy for the synthesis of the eight-membered heterocyclic skeleton of tetrahydroquinazolino[3,2-c][2,3]benzodiazocin-15-ones, based on the Pictet-Spengler reaction of 3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one with carbonyl compounds in acidic media, is proposed.
引用
收藏
页码：1006 / 1013
页数：8
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