MODIFICATION OF THE PICTET-SPENGLER REACTION IN THE SYNTHESIS OF FUSED 2,3-BENZODIAZOCINES

被引：2

作者：

Tolkunov, A. S. ^{[1
]}

Baumer, V. N. ^{[2
]}

Palamarchuk, G. V. ^{[2
]}

Shishkin, O. V. ^{[2
,3
]}

Mazepa, A. V. ^{[4
]}

Tolkunov, S. V. ^{[1
]}

Bogza, S. L. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, LM Litvinenko Inst Phys Organ Chem & Coal Chem, UA-83114 Donetsk, Ukraine

[2] Natl Acad Sci Ukraine, Inst Single Crystals, Res Branch Chem Funct Mat, UA-61001 Kharkov, Ukraine

[3] Kharkov Natl Univ, UA-61077 Kharkov, Ukraine

[4] Natl Acad Sci Ukraine, AV Bogatsky Physicochem Inst, UA-65080 Odessa, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 08期

关键词：

3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one; fused diazocines; hydrochloric acid; tetrahydroquinazolino[3,2-c][2,3]benzodiazocin-15-ones; trifluoroacetic acid; cyclization; Pictet-Spengler reaction; N-NITRENES; INTRAMOLECULAR REACTIONS; DERIVATIVES; ALKENES;

D O I：

10.1007/s10593-011-0867-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for the synthesis of the eight-membered heterocyclic skeleton of tetrahydroquinazolino[3,2-c][2,3]benzodiazocin-15-ones, based on the Pictet-Spengler reaction of 3-amino-2-[2-(3,4-dimethoxyphenyl)ethyl]quinazolin-4(3H)-one with carbonyl compounds in acidic media, is proposed.

引用

页码：1006 / 1013

页数：8

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