Biomaterials for Bone Regenerative Engineering

被引：303

作者：

Yu, Xiaohua ^{[1
,2
,3
]}

Tang, Xiaoyan ^{[1
,4
]}

Gohil, Shalini V. ^{[1
,3
,4
]}

Laurencin, Cato T. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Inst Regenerat Engn, Farmington, CT 06030 USA

[2] Univ Connecticut, Ctr Hlth, Raymond & Beverly Sackler Ctr Biomed Biol Phys &, Farmington, CT 06030 USA

[3] Univ Connecticut, Ctr Hlth, Dept Orthopaed Surg, Farmington, CT 06030 USA

[4] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06268 USA

[5] Univ Connecticut, Dept Biomed Engn, Storrs, CT 06268 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2015年 / 4卷 / 09期

关键词：

bone; osteogenesis; biomaterials; regenerative engineering; composites; DIPEPTIDE-BASED POLYPHOSPHAZENE; CERAMIC COMPOSITE SCAFFOLDS; CALCIUM-PHOSPHATE CERAMICS; BETA-TRICALCIUM PHOSPHATE; IN-VITRO EVALUATION; GROWTH-FACTOR; OSTEOBLAST ADHESION; MECHANICAL-PROPERTIES; DRUG-DELIVERY; CELL-ADHESION;

D O I：

10.1002/adhm.201400760

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the tissue engineering concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as regenerative engineering. In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. The exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration is highlighted. Particular attention is given to the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts.

引用

页码：1268 / 1285

页数：18

共 286 条

[1] Conducting-polymer nanotubes for controlled drug release [J].