Reduced prefrontal activation during performance of the Iowa Gambling Task in patients with bipolar disorder

被引：28

作者：

Ono, Yasuki ^{[1
,2
]}

Kikuchi, Mitsuru ^{[1
,3
]}

Hirosawa, Tetsu ^{[1
]}

Hino, Shoryoku ^{[4
]}

Nagasawa, Tatsuya ^{[1
]}

Hashimoto, Takanori ^{[1
]}

Munesue, Toshio ^{[1
,3
]}

Minabe, Yoshio ^{[1
,3
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Psychiat & Neurobiol, Kanazawa, Ishikawa, Japan

[2] Komatsu City Hosp, Dept Psychiat, Komatsu, Ishikawa 9238560, Japan

[3] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa, Japan

[4] Ishikawa Prefectural Takamatsu Hosp, Dept Neuropsychiat, Kahoku, Ishikawa, Japan

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2015年 / 233卷 / 01期

基金：

日本科学技术振兴机构;

关键词：

Bipolar disorder; Near-infrared spectroscopy; Autonomic activity; NEAR-INFRARED SPECTROSCOPY; VERBAL FLUENCY TASK; DECISION-MAKING; INDUCED DEACTIVATION; RATING-SCALE; CORTEX; SCHIZOPHRENIA; DEPRESSION; INDIVIDUALS; OXYGENATION;

D O I：

10.1016/j.pscychresns.2015.04.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Iowa Gambling Task (IGT) is a complex decision-making task in which monetary wins and losses guide the development of strategies. The objective of this study was to evaluate hemodynamic responses of patients with bipolar disorder (BD) during performance of the IGT using near-infrared spectroscopy (NIRS). Participants comprised 13 patients and 15 healthy control subjects who were matched for age, sex, handedness, and intelligence quotient. Relative changes in oxygenated and deoxygenated hemoglobin (oxy-Hb and deoxy-Hb) levels in the frontal region were measured using a 46-channel NIRS system. All subjects were evaluated citing NIRS during a verbal fluency task (VFT) and the IGT. During performance of the IGT. BD patients showed significantly decreased oxy-Hb levels in the bilateral orbitofrontal cortex (OFC) and left prefrontal cortex (PFC) compared with normal control subjects. However, during the VFT, patients with BD showed no significant changes in oxy-Hb levels compared with control subjects. Changes in oxy-Hb levels in the bilateral OFC and the PFC during the IGT were negatively correlated with total scores on the Hamilton Rating Scale for Depression (HAM-D). Although the IGT was useful for differentiating patients with BP from control subjects, no significant differences in autonomic activity were observed. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

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