Repression of M-phase phosphoprotein 8 inhibits melanoma growth and metastasis in vitro and in vivo

被引：0

作者：

Yuan, Bo ^{[1
]}

Lin, Lei ^{[2
]}

Ying, Zhen-Yi ^{[1
]}

Ying, Meng-Xia ^{[1
]}

Zhou, Qiong-Yan ^{[1
]}

Shi, Lei ^{[1
]}

机构：

[1] Ningbo Univ, Affiliated Hosp, Dept Dermatol, Med Sch, Ningbo 315020, Zhejiang, Peoples R China

[2] Ningbo Coll Hlth Sci, Dept Aesthet Med, Ningbo, Zhejiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2017年 / 10卷 / 12期

关键词：

melanoma; MPP8; growth; metastasis; MOLECULAR-BASIS; MPP8; METABOLISM;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Metastatic melanoma accounts for the majority of skin cancer deaths due to its aggressiveness and high resistance to current therapies. M-phase phosphoprotein 8 (MPP8) has been shown to bind to methylated H3K9 and promote tumor cell motility and invasion. The current study aimed to investigate the role of MPP8 in melanoma growth and metastasis. Our results showed that MMP8 was up-regulated in the metastatic melanoma specimens. Knockdown of MPP8 inhibited melanoma cell growth both in vitro and in vivo. Furthermore, down-regulation of MPP8 induced S-phase cell cycle arrest as well as altered expression of cell cycle-related proteins in melanoma cells. In addition, repression of MPP8 inhibited the migration and invasion of melanoma cells both in vitro and in vivo. Taken together, these data suggest that MPP8 knockdown could inhibit the growth and metastasis of melanoma cells and provide novel therapeutic target for melanoma treatment.

引用

页码：12003 / 12009

页数：7

共 21 条

[1] MOLECULAR THEMES IN ONCOGENESIS [J].

BISHOP, JM .

CELL, 1991, 64 (02) :235-248

[2] Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon [J].

Branco-Price, Cristina ;

Evans, Colin E. ;

Johnson, Randall S. .

ONCOTARGET, 2013, 4 (12) :2567-2576

[3] Epigenome Microarray Platform for Proteome-Wide Dissection of Chromatin-Signaling Networks [J].

Bua, Dennis J. ;

Kuo, Alex J. ;

Cheung, Peggie ;

Liu, Chih Long ;

Migliori, Valentina ;

Espejo, Alexsandra ;

Casadio, Fabio ;

Bassi, Christian ;

Amati, Bruno ;

Bedford, Mark T. ;

Guccione, Ernesto ;

Gozani, Or .

PLOS ONE, 2009, 4 (08)

[4] Structural Insights for MPP8 Chromodomain Interaction with Histone H3 Lysine 9: Potential Effect of Phosphorylation on Methyl-Lysine Binding [J].

Chang, Yanqi ;

Horton, John R. ;

Bedford, Mark T. ;

Zhang, Xing ;

Cheng, Xiaodong .

JOURNAL OF MOLECULAR BIOLOGY, 2011, 408 (05) :807-814

[5] Molecular Origins of Cancer Molecular Basis of Metastasis [J].

Chiang, Anne C. ;

Massague, Joan .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (26) :2814-2823

[6]

CHIBA M, 1991, INVAS METAST, V11, P288

[7] Safety, Correlative Markers, and Clinical Results of Adjuvant Nivolumab in Combination with Vaccine in Resected High-Risk Metastatic Melanoma [J].

Gibney, Geoffrey T. ;

Kudchadkar, Ragini R. ;

DeConti, Ronald C. ;

Thebeau, Melissa S. ;

Czupryn, Maria P. ;

Tetteh, Leticia ;

Eysmans, Cabell ;

Richards, Allison ;

Schell, Michael J. ;

Fisher, Kate J. ;

Horak, Christine E. ;

Inzunza, H. David ;

Yu, Bin ;

Martinez, Alberto J. ;

Younos, Ibrahim ;

Weber, Jeffrey S. .

CLINICAL CANCER RESEARCH, 2015, 21 (04) :712-720

[8] Molecular Basis for the Critical Role of Suppressor of Cytokine Signaling-1 in Melanoma Brain Metastasis [J].

Huang, Feng-Ju ;

Steeg, Patricia S. ;

Price, Janet E. ;

Chiu, Wen-Tai ;

Chou, Ping-Chieh ;

Me, Keping ;

Sawaya, Raymond ;

Huang, Suyun .

CANCER RESEARCH, 2008, 68 (23) :9634-9642

[9]

Jemal A, 2010, CA-CANCER J CLIN, V60, P277, DOI [10.3322/caac.21254, 10.3322/caac.20073]

[10]

Kirk R, 2012, NAT REV CLIN ONCOL, V9, P1, DOI [10.1038/nrclinonc.2011.196, 10.1038/nrclinonc.2012.26]

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