Synthesis and biological evaluation of novel 2-(1H-imidazol-2-ylmethylidene)hydrazinyl-1,3-thiazoles as potential antimicrobial agents

被引：6

作者：

Laczkowski, Krzysztof Z. ^{[1
]}

Jachowicz, Katarzyna ^{[2
]}

Misiura, Konrad ^{[2
]}

Biernasiuk, Anna ^{[3
]}

Malm, Anna ^{[3
]}

机构：

[1] Nicholas Copernicus Univ, Coll Med, Fac Pharm, Dept Chem Technol & Pharmaceut, Jurasza 2, PL-85089 Bydgoszcz, Poland

[2] Nicholas Copernicus Univ, Coll Med, Fac Pharm, Dept Chem Technol & Pharmaceut, PL-85089 Bydgoszcz, Poland

[3] Med Univ Lublin, Fac Pharm, Dept Pharmaceut Microbiol, PL-20093 Lublin, Poland

来源：

HETEROCYCLIC COMMUNICATIONS | 2015年 / 21卷 / 02期

关键词：

antibacterial drugs; antifungal drugs; Candida species; imidazole; thiazole; ANTIPROLIFERATIVE ACTIVITY; MOLECULAR DOCKING; ANTIBACTERIAL;

D O I：

10.1515/hc-2014-0194

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis, characterization, and investigation of antimicrobial activities of nine novel imidazolylthiazoles are presented. Their structures were determined using H-1 NMR, C-13 NMR, and elemental analysis. Compounds 3e and 3i show very strong or strong bacteriostatic or bactericidal activity [minimal bactericidal concentration/minimal inhibitory concentration (MIC) = 2-64] against Staphylococcus spp. (MIC = 7.81-15.62 mu g/mL), Micrococcus luteus ATCC 10240 (MIC = 1.95-3.91 mu g/mL), and Bacillus spp. (MIC = 3.91-15.62 mu g/mL). Compounds 3e and 3i also show the highest fungicidal effect (minimal fungicidal concentration/MIC = 2-4) against reference strains of fungi belonging to Candida spp. with MIC ranging from 3.91 to 31.25 mu g/mL.

引用

页码：109 / 114

页数：6

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