Antimicrobial polyethyleneimine-silver nanoparticles in a stable colloidal dispersion

被引：98

作者：

Lee, Hyun Ju ^{[2
]}

Lee, Se Guen ^{[2
]}

Oh, Eun Jung ^{[3
]}

Chung, Ho Yun ^{[3
]}

Han, Sang Ik ^{[4
]}

Kim, Eun Jung ^{[1
]}

Seo, Song Yi ^{[1
]}

Do Ghim, Han ^{[1
]}

Yeum, Jeong Hyun ^{[1
]}

Choi, Jin Hyun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Dept Adv Organ Mat Sci & Engn, Taegu 702701, South Korea

[2] Daegu Gyungbuk Inst Sci & Technol, Div Nano & Bio Technol, Taegu 711873, South Korea

[3] Kyungpook Natl Univ Hosp, Dept Plast & Reconstruct Surg, Taegu 700721, South Korea

[4] Natl Inst Crop Sci, Dept Funct Crop, Div Funct Crop Resource Dev, Miryang 627803, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2011年 / 88卷 / 01期

关键词：

Silver nanoparticles; Stability; Antimicrobial activity; Polyethyleneimine; Sodium borohydride; Cytotoxicity; ONE-STEP SYNTHESIS; GOLD NANOPARTICLES; IN-VITRO; ESCHERICHIA-COLI; ANTIBACTERIAL PROPERTIES; OPTICAL-ABSORPTION; HYDROGEN EVOLUTION; METAL PARTICLES; SIZE CONTROL; NOBLE-METAL;

D O I：

10.1016/j.colsurfb.2011.07.041

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Excellent colloidal stability and antimicrobial activity are important parameters for silver nanoparticles (AgNPs) in a range of biomedical applications. In this study, polyethyleneimine (PEI)-capped silver nanoparticles (PEI-AgNPs) were synthesized in the presence of sodium borohydride (NaBH4) and PEI at room temperature. The PEI-AgNPs had a positive zeta potential of approximately +49 mV, and formed a stable nanocolloid against agglomeration due to electrostatic repulsion. The particle size and hydrodynamic cluster size showed significant correlations with the amount of PEI and NaBH4. PEI-AgNPs and even PEI showed excellent antimicrobial activity against Staphylococus aureus and Klebsiella pneumoniae. The cytotoxic effects of PEI and PEI-AgNPs were confirmed by an evaluation of the cell viability. The results suggest that the amount of PEI should be minimized to the level that maintains the stability of PEI-AgNPs in a colloidal dispersion. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：505 / 511

页数：7

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