Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells

被引：155

作者：

Stelzig, Kimberly E. ^{[1
]}

Canepa-Escaro, Fabrizio ^{[2
]}

Schiliro, Marta ^{[1
]}

Berdnikovs, Sergejs ^{[3
]}

Prakash, Y. S. ^{[1
,4
]}

Chiarella, Sergio E. ^{[5
]}

机构：

[1] Mayo Clin, Dept Anesthesiol & Perioperat Med, Rochester, MN USA

[2] Univ Kentucky, Med Ctr, Dept Internal Med, Div Hosp Med, Lexington, KY USA

[3] Northwestern Univ, Dept Med, Div Allergy & Immunol, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA

[5] Mayo Clin, Div Allerg Dis, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2020年 / 318卷 / 06期

关键词：

coronavirus; COVID-19; epithelial cells; estrogen; SARS-CoV-2; RESPIRATORY SYNDROME CORONAVIRUS;

D O I：

10.1152/ajplung.00153.2020

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

There is marked sexual dimorphism in the current coronavirus disease 2019 (COVID-19) pandemic. Here we report that estrogen can regulate the expression of angiotensin-converting enzyme 2 (ACE2), a key component for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry, in differentiated airway epithelial cells. Further studies are required to elucidate the mechanisms by which sex steroids regulate SARS-CoV-2 infectivity.

引用

页码：L1280 / L1281

页数：2

共 11 条

[1] The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health [J].

Alghamdi, Ibrahim G. ;

Hussain, Issam I. ;

Almalki, Shaia S. ;

Alghamdi, Mohamed S. ;

Alghamdi, Mansour M. ;

El-Sheemy, Mohammed A. .

INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2014, 7 :417-423

[2] Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection [J].

Channappanavar, Rudragouda ;

Fett, Craig ;

Mack, Matthias ;

Ten Eyck, Patrick P. ;

Meyerholz, David K. ;

Perlman, Stanley .

JOURNAL OF IMMUNOLOGY, 2017, 198 (10) :4046-4053

[3] Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J].

Chen, Nanshan ;

Zhou, Min ;

Dong, Xuan ;

Qu, Jieming ;

Gong, Fengyun ;

Han, Yang ;

Qiu, Yang ;

Wang, Jingli ;

Liu, Ying ;

Wei, Yuan ;

Xia, Jia'an ;

Yu, Ting ;

Zhang, Xinxin ;

Zhang, Li .

LANCET, 2020, 395 (10223) :507-513

[4] Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy Early Experience and Forecast During an Emergency Response [J].

Grasselli, Giacomo ;

Pesenti, Antonio ;

Cecconi, Maurizio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (16) :1545-1546

[5]

Guan WJ, 2020, NEW ENGL J MED, V382, P1861, DOI 10.1056/NEJMc2005203

[6]

Hoffmann Markus, 2020, bioRxiv, DOI [10.1016/j.ebiom.2021.103255, 10.1101/2020.08.05.237651]

[7] ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia [J].

Jia, HP ;

Look, DC ;

Shi, L ;

Hickey, M ;

Pewe, L ;

Netland, J ;

Farzan, M ;

Wohlford-Lenane, C ;

Perlman, S ;

McCray, PB .

JOURNAL OF VIROLOGY, 2005, 79 (23) :14614-14621

[8] Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? [J].

Karlberg, J ;

Chong, DSY ;

Lai, WYY .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2004, 159 (03) :229-231

[9] Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 [J].

Li, WH ;

Zhang, CS ;

Sui, JH ;

Kuhn, JH ;

Moore, MJ ;

Luo, SW ;

Wong, SK ;

Huang, IC ;

Xu, KM ;

Vasilieva, N ;

Murakami, A ;

He, YQ ;

Marasco, WA ;

Guan, Y ;

Choe, HY ;

Farzan, M .

EMBO JOURNAL, 2005, 24 (08) :1634-1643

[10] A new mathematical model for relative quantification in real-time RT-PCR [J].

Pfaffl, MW .

NUCLEIC ACIDS RESEARCH, 2001, 29 (09) :E45

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