Immunomodulating Nanomedicine for Cancer Therapy

被引:128
作者
Liu, Zhigang [1 ,2 ]
Jiang, Wen [2 ]
Nam, Jutaek [3 ,4 ]
Moon, James J. [3 ,4 ,5 ]
Kim, Betty Y. S. [6 ,7 ,8 ]
机构
[1] Cent South Univ, Hunan Canc Hosp, Key Lab Translat Radiat Oncol, Dept Radiotherapy,Affiliated Canc Hosp,Xiangya Sc, Changsha 410013, Hunan, Peoples R China
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA
[3] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA
[6] Mayo Clin, Dept Neurosurg, Jacksonville, FL 32224 USA
[7] Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA
[8] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
基金
中国国家自然科学基金;
关键词
Nanomedicine; cancer immunotherapy; cancer vaccine; drug delivery; nanotechnology; ANTIGEN-PRESENTING CELLS; RNA DELIVERY; T-CELLS; NANOPARTICLES; EXPANSION; AGONISTS; DESIGN; DEATH;
D O I
10.1021/acs.nanolett.8b02340
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanomaterials offer unique advantages as drug-delivery vehicles for cancer therapeutics. For immuno-oncology applications, cancer nanomedicine should be developed beyond drug-delivery platforms. A greater emphasis on actively modulating host anticancer immunity using nanomaterials provides new avenues for developing novel cancer therapeutics.
引用
收藏
页码:6655 / 6659
页数:5
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