Immunomodulating Nanomedicine for Cancer Therapy

被引：128

作者：

Liu, Zhigang ^{[1
,2
]}

Jiang, Wen ^{[2
]}

Nam, Jutaek ^{[3
,4
]}

Moon, James J. ^{[3
,4
,5
]}

Kim, Betty Y. S. ^{[6
,7
,8
]}

机构：

[1] Cent South Univ, Hunan Canc Hosp, Key Lab Translat Radiat Oncol, Dept Radiotherapy,Affiliated Canc Hosp,Xiangya Sc, Changsha 410013, Hunan, Peoples R China

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA

[3] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[6] Mayo Clin, Dept Neurosurg, Jacksonville, FL 32224 USA

[7] Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA

[8] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

NANO LETTERS | 2018年 / 18卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Nanomedicine; cancer immunotherapy; cancer vaccine; drug delivery; nanotechnology; ANTIGEN-PRESENTING CELLS; RNA DELIVERY; T-CELLS; NANOPARTICLES; EXPANSION; AGONISTS; DESIGN; DEATH;

D O I：

10.1021/acs.nanolett.8b02340

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanomaterials offer unique advantages as drug-delivery vehicles for cancer therapeutics. For immuno-oncology applications, cancer nanomedicine should be developed beyond drug-delivery platforms. A greater emphasis on actively modulating host anticancer immunity using nanomaterials provides new avenues for developing novel cancer therapeutics.

引用

页码：6655 / 6659

页数：5

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