Review Cancer vaccines: Building a bridge over troubled waters

被引：156

作者：

Sellars, MacLean C. ^{[1
]}

Wu, Catherine J. ^{[1
,2
,3
,4
]}

Fritsch, Edward F. ^{[1
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[4] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

来源：

CELL | 2022年 / 185卷 / 15期

关键词：

T-CELL RESPONSES; DENDRITIC CELLS; NEOANTIGEN VACCINE; IMMUNOTHERAPY; TOLERANCE; MELANOMA; IMMUNITY; ANTIGENS; SURVIVAL; IMMUNOLOGY;

D O I：

10.1016/j.cell.2022.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review the essential immunologic concepts underpinning natural immunity and highlight the multiple unique challenges faced by vaccines targeting cancer. Recent technological advances in mass spectrometry, neoantigen prediction, genetically and pharmacologically engineered mouse models, and single-cell omics have revealed new biology, which can help to bridge this divide. We particularly focus on translationally relevant aspects, such as antigen selection and delivery and the monitoring of human post-vaccination responses, and encourage more aggressive exploration of novel approaches.

引用

页码：2770 / 2788

页数：19

共 142 条

[61] Antigen kinetics determines immune reactivity [J].

Johansen, Pal ;

Storni, Tazio ;

Rettig, Lorna ;

Qiu, Zhiyong ;

Der-Sarkissian, Ani ;

Smith, Kent A. ;

Manolova, Vania ;

Lang, Karl S. ;

Senti, Gabriela ;

Muellhaupt, Beat ;

Gerlach, Tillman ;

Speck, Roberto F. ;

Bot, Adrian ;

Kuendig, Thomas M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5189-5194

[62] The precursors of CD8(+) tissue resident memory T cells: from lymphoid organs to infected tissues [J].

Kok, Lianne ;

Masopust, David ;

Schumacher, Ton N. .

NATURE REVIEWS IMMUNOLOGY, 2022, 22 (05) :283-293

[63] Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant [J].

Korsholm, Karen Smith ;

Hansen, Jon ;

Karlsen, Kasper ;

Filskov, Jonathan ;

Mikkelsen, Marianne ;

Lindenstrom, Thomas ;

Schmidt, Signe Tandrup ;

Andersen, Peter ;

Christensen, Dennis .

VACCINE, 2014, 32 (31) :3927-3935

[64] Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy [J].

Kranz, Lena M. ;

Diken, Mustafa ;

Haas, Heinrich ;

Kreiter, Sebastian ;

Loquai, Carmen ;

Reuter, Kerstin C. ;

Meng, Martin ;

Fritz, Daniel ;

Vascotto, Fulvia ;

Hefesha, Hossam ;

Grunwitz, Christian ;

Vormehr, Mathias ;

Huesemann, Yves ;

Selmi, Abderraouf ;

Kuhn, Andreas N. ;

Buck, Janina ;

Derhovanessian, Evelyna ;

Rae, Richard ;

Attig, Sebastian ;

Diekmann, Jan ;

Jabulowsky, Robert A. ;

Heesch, Sandra ;

Hassel, Jessica ;

Langguth, Peter ;

Grabbe, Stephan ;

Huber, Christoph ;

Tuereci, Oezlem ;

Sahin, Ugur .

NATURE, 2016, 534 (7607) :396-+

[65] Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma [J].

Kristensen, Nikolaj Pagh ;

Heeke, Christina ;

Tvingsholm, Siri A. ;

Borch, Annie ;

Draghi, Arianna ;

Crowther, Michael D. ;

Carri, Ibel ;

Munk, Kamilla K. ;

Holm, Jeppe Sejero ;

Bjerregaard, Anne-Mette ;

Bentzen, Amalie Kai ;

Marquard, Andrea M. ;

Szallasi, Zoltan ;

McGranahan, Nicholas ;

Andersen, Rikke ;

Nielsen, Morten ;

Jonsson, Goran B. ;

Donia, Marco ;

Svane, Inge Marie ;

Hadrup, Sine Reker .

JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (02)

[66] Cell Therapy With TILs: Training and Taming T Cells to Fight Cancer [J].

Kumar, Amrendra ;

Watkins, Reese ;

Vilgelm, Anna E. .

FRONTIERS IN IMMUNOLOGY, 2021, 12

[67] Human T Cell Development, Localization, and Function throughout Life [J].

Kumar, Brahma V. ;

Connors, Thomas J. ;

Farber, Donna L. .

IMMUNITY, 2018, 48 (02) :202-213

[68] Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer [J].

Lal, Jessica Castrillon ;

Townsend, Madeline G. ;

Mehta, Anita K. ;

Oliwa, Madisson ;

Miller, Eric ;

Sotayo, Alaba ;

Cheney, Emily ;

Mittendorf, Elizabeth A. ;

Letai, Anthony ;

Guerriero, Jennifer L. .

BREAST CANCER RESEARCH, 2021, 23 (01)

[69] An Empirical Antigen Selection Method Identifies Neoantigens That Either Elicit Broad Antitumor T-cell Responses or Drive Tumor Growth [J].

Lam, Hubert ;

McNeil, Lisa K. ;

Starobinets, Hanna ;

DeVault, Victoria L. ;

Cohen, Roger B. ;

Twardowski, Przemyslaw ;

Johnson, Melissa L. ;

Gillison, Maura L. ;

Stein, Mark N. ;

Vaishampayan, Ulka N. ;

DeCillis, Arthur P. ;

Foti, James J. ;

Vemulapalli, Vijetha ;

Tjon, Emily ;

Ferber, Kyle ;

DeOliveira, Daniel B. ;

Broom, Wendy ;

Agnihotri, Parul ;

Jaffee, Elizabeth M. ;

Wong, Kwok-Kin ;

Drake, Charles G. ;

Carroll, Pamela M. ;

Davis, Thomas A. ;

Flechtner, Jessica Baker .

CANCER DISCOVERY, 2021, 11 (03) :696-713

[70] The role of dendritic cells in cancer [J].

Lee, Yoke Seng ;

Radford, Kristen J. .

IMMUNOBIOLOGY OF DENDRITIC CELLS, PT A, 2019, 348 :123-178

← 2 3 4 5 6 7 8 9 10 11 →