Review Cancer vaccines: Building a bridge over troubled waters

被引：156

作者：

Sellars, MacLean C. ^{[1
]}

Wu, Catherine J. ^{[1
,2
,3
,4
]}

Fritsch, Edward F. ^{[1
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[4] Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA

来源：

CELL | 2022年 / 185卷 / 15期

关键词：

T-CELL RESPONSES; DENDRITIC CELLS; NEOANTIGEN VACCINE; IMMUNOTHERAPY; TOLERANCE; MELANOMA; IMMUNITY; ANTIGENS; SURVIVAL; IMMUNOLOGY;

D O I：

10.1016/j.cell.2022.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review the essential immunologic concepts underpinning natural immunity and highlight the multiple unique challenges faced by vaccines targeting cancer. Recent technological advances in mass spectrometry, neoantigen prediction, genetically and pharmacologically engineered mouse models, and single-cell omics have revealed new biology, which can help to bridge this divide. We particularly focus on translationally relevant aspects, such as antigen selection and delivery and the monitoring of human post-vaccination responses, and encourage more aggressive exploration of novel approaches.

引用

页码：2770 / 2788

页数：19

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