Honeysuckle Extract Plays a Protective Role in Spinal Cord Injury Recovery by Regulating PI3K/Akt Signaling Pathway

被引：0

作者：

Cheng, Hongjuan ^{[1
]}

You, Guopeng ^{[1
]}

Dong, Haoyu ^{[2
]}

Wei, Jie ^{[1
]}

Yang, Luran ^{[1
]}

机构：

[1] Changzhi Med Coll, Dept Publ Sports, 161 Jiefang East St, Changzhi 046000, Shanxi, Peoples R China

[2] Changzhi Med Coll, Dept Endocrinol, Heping Hosp, Changzhi 046000, Shanxi, Peoples R China

来源：

CURRENT TOPICS IN NUTRACEUTICAL RESEARCH | 2022年 / 20卷 / 01期

关键词：

Apoptosis; Honeysuckle; Inflammation; Lonicera japonicae; PI3K/Akt pathway; Spinal cord injury; ACTIVATION;

D O I：

10.37290/ctnr2641-452X.20:135-140

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Spinal cord injury (SCI) is a traumatic injury leading to hypoxia, lipid peroxidation, and cellular apoptosis. Honeysuckle (Lonicera japonicae) has been used to treat headaches and play a neuroprotective role. However, its possible effects on protection from neurological function loss during injury remain to be explored. To this end, we have investigated the effects of honeysuckle extract on neural function injury in SCI rats and report an improvement in nerve function. The mechanism involved reduced expression of proinflammatory cytokines, decrease in cellular apoptosis, and activation of PI3K/Akt pathway. We conclude that possible use of honeysuckle extract for treatment of SCI needs further exploration.

引用

页码：135 / 140

页数：6

共 50 条

[1] The role of PI3K/Akt signalling pathway in spinal cord injury
Xiao, Chun-Lin
Yin, Wen-Chao
Zhong, Yan-Chun
Luo, Jia-Quan
Liu, Lu-Lin
Liu, Wu-Yang
Zhao, Kai
BIOMEDICINE & PHARMACOTHERAPY, 2022, 156
[2] The role of PI3K/Akt/eNOS pathway in spinal cord injury and the recovery of motor function
Wang, Longqiang
Sun, Haiwei
Fu, Song
Shao, Shize
Hou, Haitao
Liu, Xiaolan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2020, 13 (07): : 4960 - 4965
[3] Pectolinarin Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglia Polarization Through the PI3K/AKT Signaling Pathway
Wang, Chenggui
Li, Jiawei
Wu, Chenyu
Wu, Zhouwei
Jiang, Zhichen
Hong, Chenglong
Ying, Juntao
Chen, Fancheng
Yang, Qi
Xu, Hui
Sheng, Sunren
Feng, Yongzeng
MOLECULAR NEUROBIOLOGY, 2025,
[4] The change tendency of PI3K/Akt pathway after spinal cord injury
Zhang, Peixun
Zhang, Luping
Zhu, Lei
Chen, Fangmin
Zhou, Shuai
Tian, Ting
Zhang, Yuqiang
Jiang, Xiaorui
Li, Xuekun
Zhang, Chuansen
Xu, Lin
Huang, Fei
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2015, 7 (11): : 2223 - 2232
[5] Repairing effects of liraglutide on spinal cord injury in ratsvia PI3K/AKT/ENOS signaling pathway
Qi, T. -M.
Wang, F. -R.
Fan, C. -M.
Liu, L. -M.
Zhou, J. -Y.
Lin, X. -C.
Suonan, A. -X.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2020, 34 (06): : 2083 - 2089
[6] The role of the PI3K/Akt/mTOR pathway in glial scar formation following spinal cord injury
Chen, Chun-Hong
Sung, Chun-Sung
Huang, Shi-Ying
Feng, Chien-Wei
Hung, Han-Chun
Yang, San-Nan
Chen, Nan-Fu
Tai, Ming-Hong
Wen, Zhi-Hong
Chen, Wu-Fu
EXPERIMENTAL NEUROLOGY, 2016, 278 : 27 - 41
[7] Resveratrol Regulates Cellular Activity through the PI3K/AKT Signaling Pathway Involved in Spinal Cord Injury
Xiang, Zimin
Fang, Dingxi
Zhang, Yuxuan
Zhang, Qi
Sun, Yuping
Li, Liyan
Zhang, Xiaoqian
Li, Jiaxin
Ding, Lingzhi
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2024, 38 (02): : 1673 - 1683
[8] The PI3K/Akt/mTOR signaling pathway plays a role in regulating aconitine-induced autophagy in mouse liver
Yang, Hanqi
Wang, Hui
Liu, Yanbing
Yang, Lin
Sun, Lu
Tian, Yanan
Zhao, Baoyu
Lu, Hao
RESEARCH IN VETERINARY SCIENCE, 2019, 124 : 317 - 320
[9] MicroRNA-489-3p inhibits neurite growth by regulating PI3K/AKT pathway in spinal cord injury
Jiang, Rui
Zhang, Chao
Gu, Rui
Wu, Han
PHARMAZIE, 2017, 72 (05): : 272 - 278
[10] The PI3K/AKT/MTOR signaling pathway: The role of PI3K and AKT inhibitors in breast cancer
Huemer F.
Bartsch R.
Gnant M.
Current Breast Cancer Reports, 2014, 6 (2) : 59 - 70

← 1 2 3 4 5 →