Characterisation of dirithromycin and spiramycin using high performance liquid chromatography and direct infusion mass spectrometry

被引：16
作者：
de la Huebra, MJG [1 ]
Vincent, U [1 ]
Bordin, G [1 ]
Rodríguez, AR [1 ]
机构：
[1] Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements, B-2440 Geel, Belgium
来源：
ANALYTICA CHIMICA ACTA | 2004年 / 503卷 / 02期
关键词：
macrolide antibiotics; coulometric detection; high performance liquid chromatography; mass spectrometry;
D O I：
10.1016/j.aca.2003.10.037
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Two different high performance liquid chromatography procedures and two detection modes (spectrophotometric and electrochemical) and direct infusion mass spectrometry were used for the characterisation of two macrolide antibiotics, spiramycin and dirithromycin, showing multisignal response in liquid chromatography. In the spiramycin standard three forms were determined qualitatively and quantitatively. The degradation metabolite of dirithromycin, erythromycylamine, was also identified. (C) 2003 Elsevier B.V. All rights reserved.
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收藏
页码：247 / 256
页数：10
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