Molecular targets for breast cancer therapy and prevention

被引：229

作者：

Bange, J ^{[1
]}

Zwick, E ^{[1
]}

Ullrich, A ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany

来源：

NATURE MEDICINE | 2001年 / 7卷 / 05期

关键词：

D O I：

10.1038/87872

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent completion of the human genome sequence has raised great hopes in the discovery of new breast cancer therapies based on newly-discovered genes linked to breast cancer development and progression. Here we describe breast cancer therapies that have emerged from gene-base scientific efforts over the past 20 years and that are now approved for clinical testing or treatment.

引用

页码：548 / 552

页数：5

共 66 条

[1] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2] OVEREXPRESSION OF HER-2 NEU AND ITS RELATIONSHIP WITH OTHER PROGNOSTIC FACTORS CHANGE DURING THE PROGRESSION OF INSITU TO INVASIVE BREAST-CANCER [J].

ALLRED, DC ;

CLARK, GM ;

MOLINA, R ;

TANDON, AK ;

SCHNITT, SJ ;

GILCHRIST, KW ;

OSBORNE, CK ;

TORMEY, DC ;

MCGUIRE, WL .

HUMAN PATHOLOGY, 1992, 23 (09) :974-979

[3] EXPRESSION OF RAS P21, P53 AND C-ERBB-2 IN ADVANCED BREAST-CANCER AND RESPONSE TO FIRST LINE HORMONAL-THERAPY [J].

ARCHER, SG ;

ELIOPOULOS, A ;

SPANDIDOS, D ;

BARNES, D ;

ELLIS, IO ;

BLAMEY, RW ;

NICHOLSON, RI ;

ROBERTSON, JFR .

BRITISH JOURNAL OF CANCER, 1995, 72 (05) :1259-1266

[4] Clinical trials of Herceptin® (trastuzumab) [J].

Baselga, J .

EUROPEAN JOURNAL OF CANCER, 2001, 37 :S18-S24

[5] ONCOGENE AMPLIFICATION AND PROGNOSIS IN BREAST-CANCER - RELATIONSHIP WITH SYSTEMIC TREATMENT [J].

BERNS, EMJJ ;

FOEKENS, JA ;

VANSTAVEREN, IL ;

VANPUTTEN, WLJ ;

DEKONING, HYWCM ;

PORTENGEN, H ;

KLIJN, JGM .

GENE, 1995, 159 (01) :11-18

[6] Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance [J].

Boehm, T ;

Folkman, J ;

Browder, T ;

OReilly, MS .

NATURE, 1997, 390 (6658) :404-407

[7] ERBB2 AMPLIFICATION IS ASSOCIATED WITH TAMOXIFEN RESISTANCE IN STEROID-RECEPTOR POSITIVE BREAST-CANCER [J].

BORG, A ;

BALDETORP, B ;

FERNO, M ;

KILLANDER, D ;

OLSSON, H ;

RYDEN, S ;

SIGURDSSON, H .

CANCER LETTERS, 1994, 81 (02) :137-144

[8]

CARTER SK, 1972, CANCER-AM CANCER SOC, V30, P1543, DOI 10.1002/1097-0142(197212)30:6<1543::AID-CNCR2820300621>3.0.CO

[9]

2-V

[10]

Ciardiello F, 2000, CLIN CANCER RES, V6, P2053

← 1 2 3 4 5 6 7 →