SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE

被引：36

作者：

Shafiq, Muhammad ^{[1
]}

Zia-Ur-Rehman, Muhammad ^{[2
]}

Khan, Islam Ullah ^{[1
]}

Arshad, Muhammad Nadeem ^{[1
]}

Khan, Siraj Ahmed ^{[3
]}

机构：

[1] Govt Coll Univ, Dept Chem, Mat Chem Lab, Lahore 54000, Pakistan

[2] PCSIR Labs Complex, Appl Chem Res Ctr, Lahore 54600, Pakistan

[3] Qarshi Res Int, Microbiol Labs, Hattar, Pakistan

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2011年 / 56卷 / 01期

关键词：

2,1-Benzothiazine 2,2-dioxides; Schiff bases; Anti-bacterial activity; Methyl anthranilate;

D O I：

10.4067/S0717-97072011000100001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N'-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2 lambda(6)-benzo[c][1,2]thiazin-4-ylidene)-hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfonyl chloride, followed by N-alkylation and subsequent base catalyzed cyclization. Hydrazinolysis of the cyclized products followed by their ultrasound mediated condensations with different benzaldehydes yielded the title compounds. Some of these compounds showed good anti-bacterial activity against Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus.

引用

页码：527 / 531

页数：5

共 23 条

[1] Anti-oxidant and anti-bacterial activities of novel N′-arylmethylidene-2-(3, 4-dimethyl-5, 5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl) acetohydrazides [J].