Immune Dysregulation after Cardiothoracic Surgery and Incidental Thymectomy: Maintenance of Regulatory T Cells despite Impaired Thymopoiesis

被引：32

作者：

Halnon, Nancy J. ^{[1
]}

Cooper, Paige ^{[1
]}

Chen, Diana Yu Hui ^{[2
]}

Boechat, M. Ines ^{[1
,3
]}

Uittenbogaart, Christel H. ^{[1
,2
,4
,5
]}

机构：

[1] Univ Calif Los Angeles, Dept Pediat, David Geffen Sch Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Radiol, David Geffen Sch Med, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, AIDS Inst, David Geffen Sch Med, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

CLINICAL & DEVELOPMENTAL IMMUNOLOGY | 2011年

关键词：

ALLERGIC RHINOCONJUNCTIVITIS; CARDIOPULMONARY BYPASS; AUTOIMMUNE-DISEASE; BETA REPERTOIRE; CD4(+); POPULATIONS; COMPARTMENT; CHILDREN; PREVALENCE; MECHANISMS;

D O I：

10.1155/2011/915864

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thymectomy is performed in infants during cardiothoracic surgery leaving many patients with reduced thympopoiesis. An association between immune disorders and regulatory T cells (Treg) after incidental thymectomy has not been investigated. Questionnaires soliciting symptoms of atopic or autoimmune disease and biomarkers were measured in children and adults with congenital heart disease and either reduced or preserved thymopoiesis. Tregs were examined. Atopic or autoimmune-like symptoms and elevated anti-dsDNA antibodies were common after surgery in individuals with low thymopoiesis. Total Treg number and function were maintained but with fewer naive Treg. TCR spectratypes were similar to other memory T cells. These data suggest that thymectomy does not reduce total Treg number but homeostasis is affected with reduced naive Treg. Prevalence of autoimmune or atopic symptoms after surgery is not associated with total number or proportion of Tregs but appears to be due to otherwise unknown factors that may include altered Treg homeostasis.

引用

页数：11

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