Host response to fungal infections - how immunology and host genetics could help to identify and treat patients at risk

被引：11
作者：
Khanna, Nina [1 ,2 ,3 ]
Stuehler, Claudia [2 ,3 ]
Lunemann, Anna [4 ]
Wojtowicz, Agnieszka [5 ,6 ]
Bochud, Pierre-Yves [5 ,6 ]
Leibundgut-Landmann, Salome [7 ]
机构：
[1] Univ Basel Hosp, Div Infect Dis & Hosp Epidemiol, Petersgraben 4, CH-4031 Basel, Switzerland
[2] Univ Basel, Dept Biomed, Infect Biol Lab, CH-4003 Basel, Switzerland
[3] Univ Basel Hosp, Basel, Switzerland
[4] Univ Childrens Hosp, Expt Infect Dis & Canc Res, Zurich, Switzerland
[5] Univ Hosp, Infect Dis Serv, Lausanne, Switzerland
[6] Univ Lausanne, CH-1015 Lausanne, Switzerland
[7] Univ Zurich, Vetsuisse Fac, Immunol Sect, CH-8006 Zurich, Switzerland
来源：
SWISS MEDICAL WEEKLY | 2016年 / 146卷
基金：
瑞士国家科学基金会;
关键词：
fungal infections; Aspergillus; Candida; genetic predisposition; host genetics; immunology; antifungal therapy; adoptive T cell therapy; immunotherapy; T-CELL RESPONSES; NATURAL-KILLER-CELLS; ASPERGILLUS-FUMIGATUS PROTEINS; CLINICAL-SCALE GENERATION; INVASIVE ASPERGILLOSIS; NK CELLS; CANDIDA-ALBICANS; IFN-GAMMA; RAT MODEL; HEMATOLOGIC MALIGNANCIES;
D O I：
10.4414/smw.2016.14350
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In spite of the ever-increasing incidence and poor outcome of invasive fungal infections in immune compromised patients, there is currently no reliable method to accurately predict the risk, to monitor the outcome and to treat these infections. Protective immunity against Candida and Aspergillus depends on a highly coordinated interaction between the innate and adaptive immune systems. Genetic and immunological defects in components of these networks result in increased risk of invasive fungal infections among patients undergoing chemotherapy or transplant recipients. We review the most important genetic and immunological factors that influence human susceptibility to Candida and Aspergillus infections and discuss the potential role of basic research to promote precision medicine for infectious diseases. We discuss how immunogenetic studies can help to provide tools for improved identification of high-risk patients and the development of tailored antifungal therapies.
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收藏
页数：12
相关论文
共 126 条
[1]   Immunotherapy for fungal infections [J].
Armstrong-James, Darius ;
Harrison, Thomas S. .
CURRENT OPINION IN MICROBIOLOGY, 2012, 15 (04) :434-439
[2]   Identification of Immunogenic Antigens from Aspergillus fumigatus by Direct Multiparameter Characterization of Specific Conventional and Regulatory CD4+ T Cells [J].
Bacher, Petra ;
Kniemeyer, Olaf ;
Teutschbein, Janka ;
Thoen, Marcel ;
Voedisch, Martin ;
Wartenberg, Dirk ;
Scharf, Daniel H. ;
Koester-Eiserfunke, Nora ;
Schuette, Mark ;
Duebel, Stefan ;
Assenmacher, Mario ;
Brakhage, Axel A. ;
Scheffold, Alexander .
JOURNAL OF IMMUNOLOGY, 2014, 193 (07) :3332-3343
[3]   IL-17 Regulates Systemic Fungal Immunity by Controlling the Functional Competence of NK Cells [J].
Baer, Eva ;
Whitney, Paul G. ;
Moor, Kathrin ;
Reis e Sousa, Caetano ;
LeibundGut-Landmann, Salome .
IMMUNITY, 2014, 40 (01) :117-127
[4]   Precision Medicine [J].
Bahcall, Orli .
NATURE, 2015, 526 (7573) :335-335
[5]   Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus [J].
Beck, O ;
Topp, MS ;
Koehl, U ;
Roilides, E ;
Simitsopoulou, M ;
Hanisch, M ;
Sarfati, J ;
Latgé, JP ;
Klingebiel, T ;
Einsele, H ;
Lehrnbecher, T .
BLOOD, 2006, 107 (06) :2562-2569
[6]  
BENEDETTO N, 1988, MICROBIOLOGICA, V11, P339
[7]   Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity [J].
Bhatnagar, Nupur ;
Hong, Henoch S. ;
Krishnaswamy, Jayendra K. ;
Haghikia, Arash ;
Behrens, Georg M. ;
Schmidt, Reinhold E. ;
Jacobs, Roland .
BLOOD, 2010, 116 (08) :1308-1316
[8]   Restoration of NET formation by gene therapy in CGD controls aspergillosis [J].
Bianchi, Matteo ;
Hakkim, Abdul ;
Brinkmann, Volker ;
Siler, Ulrich ;
Seger, Reinhard A. ;
Zychlinsky, Arturo ;
Reichenbach, Janine .
BLOOD, 2009, 114 (13) :2619-2622
[9]   Increasing Incidence of Zygomycosis (Mucormycosis), France, 1997-2006 [J].
Bitar, Dounia ;
Van Cauteren, Dieter ;
Lanternier, Fanny ;
Dannaoui, Eric ;
Che, Didier ;
Dromer, Francoise ;
Desenclos, Jean-Claude ;
Lortholary, Olivier .
EMERGING INFECTIOUS DISEASES, 2009, 15 (09) :1395-1401
[10]   Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation [J].
Bochud, Pierre-Yves ;
Chien, Jason W. ;
Marr, Kieren A. ;
Leisenring, Wendy M. ;
Upton, Arlo ;
Janer, Marta ;
Rodrigues, Stephanie D. ;
Li, Sarah ;
Hansen, John A. ;
Zhao, Lue Ping ;
Aderem, Alan ;
Boeckh, Michael .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (17) :1766-1777
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