The gut microbiota in retinal diseases

被引：20

作者：

Bringer, Marie-Agnes ^{[1
]}

Gabrielle, Pierre-Henry ^{[1
,2
]}

Bron, Alain M. ^{[1
,2
]}

Creuzot-Garcher, Catherine ^{[1
,2
]}

Acar, Niyazi ^{[1
]}

机构：

[1] Univ Bourgogne Franche Comte, Ctr Sci Gout & Alimentat, Eye & Nutr Res Grp, AgroSup Dijon,CNRS,INRAE, F-21000 Dijon, France

[2] Univ Hosp, Ophthalmol Dept, F-21000 Dijon, France

来源：

EXPERIMENTAL EYE RESEARCH | 2022年 / 214卷

关键词：

Gut microbiota; Retina; Age-related macular degeneration; Diabetic retinopathy; Glaucoma; Probiotics; INTERNATIONAL SCIENTIFIC ASSOCIATION; ANGIOTENSIN-CONVERTING ENZYME-2; POLYUNSATURATED FATTY-ACIDS; INTESTINAL MICROBIOTA; DIABETIC-RETINOPATHY; LONG-CHAIN; BILE-ACIDS; TAUROURSODEOXYCHOLIC ACID; RETINITIS-PIGMENTOSA; CHRONIC INFLAMMATION;

D O I：

10.1016/j.exer.2021.108867

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The gut microbiota is a complex ecosystem that inhabits the gastrointestinal tract and consists of archaea, fungi, viruses, and bacteria, with bacteria being dominant. From birth onwards, it coevolves dynamically together with the host. The composition of the gut microbiota is under the influence of a complex interplay between both host and environmental factors. Scientific advances in the past few decades have shown that it is essential in maintaining homeostasis and tipping the balance between health and disease. In addition to its role in food digestion, the gut microbiota is implicated in regulating multiple physiological processes in the host gut mucosa and in distant organs such as the brain. Persistent imbalance between gut microbial communities, termed "dysbiosis," has been associated with several inflammatory and metabolic diseases as well as with central nervous system disorders. In this review, we present the state of the art of current knowledge on an emerging concept, the microbiota-retina axis, and the potential role of its disturbance in the development of retinopathies. We also describe several microbiota-targeting strategies that could constitute preventive and therapeutic tools for retinopathies.

引用

页数：14