Tissue-specific HIV-1 infection: why it matters

被引：15
作者：
Karris, Maile A. Y. [1 ]
Smith, Davey M. [1 ]
机构：
[1] Univ Calif San Diego, Div Infect Dis, La Jolla, CA 92037 USA
来源：
FUTURE VIROLOGY | 2011年 / 6卷 / 07期
关键词：
CNS; compartmentalization; gastrointestinal-associated lymphoid tissue; genital tract; HIV-1; HUMAN-IMMUNODEFICIENCY-VIRUS; MALE GENITAL-TRACT; T-CELL DEPLETION; COMPLEMENT ENHANCES INFECTION; INTESTINAL LAMINA PROPRIA; CEREBRAL SPINAL-FLUID; ANTIRETROVIRAL THERAPY; CEREBROSPINAL-FLUID; IMMUNE ACTIVATION; TYPE-1; INFECTION;
D O I：
10.2217/FVL.11.48
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The human immunodeficiency virus displays a narrow tropism for CD4(+) mononuclear cells, and activated CD4(+) T lymphocytes are the main target. When these cells are depleted by viral replication, bystander apoptosis and increased cell turnover mediated by immune activation, there is a progressive immunodeficiency (i.e., AIDS). Despite this specific cell tropism, HIV-infected persons demonstrate pathology in nearly every organ system. This article reviews current understanding of tissue-specific HIV-1 infection in the CNS, the genital tract, and gastrointestinal-associated lymphoid tissue.
引用
收藏
页码：869 / 882
页数：14
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  • [21] Biology of the Male Reproductive Tract: Its Cellular and Morphological Considerations
    Bronson, Richard
    [J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2011, 65 (03) : 212 - 219
  • [22] Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood-brain barrier and infection by HIV: Implications for NeuroAIDS
    Buckner, Clarisa M.
    Calderon, Tina M.
    Willams, Dionna W.
    Belbin, Thomas J.
    Berman, Joan W.
    [J]. CELLULAR IMMUNOLOGY, 2011, 267 (02) : 109 - 123
  • [23] Compartmentalization of HIV-1 within the Female Genital Tract Is Due to Monotypic and Low-Diversity Variants Not Distinct Viral Populations
    Bull, Marta
    Learn, Gerald
    Genowati, Indira
    McKernan, Jennifer
    Hitti, Jane
    Lockhart, David
    Tapia, Kenneth
    Holte, Sarah
    Dragavon, Joan
    Coombs, Robert
    Mullins, James
    Frenkel, Lisa
    [J]. PLOS ONE, 2009, 4 (09):
  • [24] Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy
    Canestri, Ana
    Lescure, Francois-Xavier
    Jaureguiberry, Stephane
    Moulignier, Antoine
    Amiel, Corinne
    Marcelin, Anne Genevieve
    Peytavin, Gilles
    Tubiana, Roland
    Pialoux, Gilles
    Katlama, Christine
    [J]. CLINICAL INFECTIOUS DISEASES, 2010, 50 (05) : 773 - 778
  • [25] Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques
    Cecchinato, V.
    Trindade, C. J.
    Laurence, A.
    Heraud, J. M.
    Brenchley, J. M.
    Ferrari, M. G.
    Zaffiri, L.
    Tryniszewska, E.
    Tsai, W. P.
    Vaccari, M.
    Parks, R. Washington
    Venzon, D.
    Douek, D. C.
    O'Shea, J. J.
    Franchini, G.
    [J]. MUCOSAL IMMUNOLOGY, 2008, 1 (04) : 279 - 288
  • [26] Th17 cells in pathogenic simian immunodeficiency virus infection of macaques
    Cecchinato, Valentina
    Franchini, Genoveffa
    [J]. CURRENT OPINION IN HIV AND AIDS, 2010, 5 (02) : 141 - 145
  • [27] Unique HIV type 1 V3 region sequences derived from six different regions of brain: Region-specific evolution within host-determined quasispecies
    Chang, J
    Jozwiak, R
    Wang, B
    Ng, T
    Ge, YC
    Bolton, W
    Dwyer, DE
    Randle, C
    Osborn, R
    Cunningham, AL
    Saksena, NK
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (01) : 25 - 30
  • [28] Extensive recombination among human immunodeficiency virus type 1 quasispecies makes an important contribution to viral diversity in individual patients
    Charpentier, C
    Nora, T
    Tenaillon, O
    Clavel, F
    Hance, AJ
    [J]. JOURNAL OF VIROLOGY, 2006, 80 (05) : 2472 - 2482
  • [29] Sigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy
    Chege, Duncan
    Sheth, Prameet M.
    Kain, Taylor
    Kim, Connie J.
    Kovacs, Colin
    Loutfy, Mona
    Halpenny, Roberta
    Kandel, Gabor
    Chun, Tae-Wook
    Ostrowski, Mario
    Kaul, Rupert
    [J]. AIDS, 2011, 25 (06) : 741 - 749
  • [30] Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses
    Choi, C
    Benveniste, EN
    [J]. BRAIN RESEARCH REVIEWS, 2004, 44 (01) : 65 - 81
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