Tissue-specific HIV-1 infection: why it matters

被引：15
作者：
Karris, Maile A. Y. [1 ]
Smith, Davey M. [1 ]
机构：
[1] Univ Calif San Diego, Div Infect Dis, La Jolla, CA 92037 USA
来源：
FUTURE VIROLOGY | 2011年 / 6卷 / 07期
关键词：
CNS; compartmentalization; gastrointestinal-associated lymphoid tissue; genital tract; HIV-1; HUMAN-IMMUNODEFICIENCY-VIRUS; MALE GENITAL-TRACT; T-CELL DEPLETION; COMPLEMENT ENHANCES INFECTION; INTESTINAL LAMINA PROPRIA; CEREBRAL SPINAL-FLUID; ANTIRETROVIRAL THERAPY; CEREBROSPINAL-FLUID; IMMUNE ACTIVATION; TYPE-1; INFECTION;
D O I：
10.2217/FVL.11.48
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The human immunodeficiency virus displays a narrow tropism for CD4(+) mononuclear cells, and activated CD4(+) T lymphocytes are the main target. When these cells are depleted by viral replication, bystander apoptosis and increased cell turnover mediated by immune activation, there is a progressive immunodeficiency (i.e., AIDS). Despite this specific cell tropism, HIV-infected persons demonstrate pathology in nearly every organ system. This article reviews current understanding of tissue-specific HIV-1 infection in the CNS, the genital tract, and gastrointestinal-associated lymphoid tissue.
引用
收藏
页码：869 / 882
页数：14
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