Naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate

被引：1

作者：

Fall, Serigne Abdou Khadir ^{[1
]}

Hajib, Sara ^{[1
]}

Karai, Oumaima ^{[1
]}

Boukhssas, Salaheddine ^{[1
]}

Aouine, Younas ^{[1
,2
]}

Akhazzane, Mohamed ^{[1
,3
]}

Labriti, Brahim ^{[1
]}

Faraj, Hassane ^{[1
]}

Alami, Anouar ^{[1
]}

机构：

[1] Sidi Mohammed Ben Abdellah Univ, Fac Sci Dhar El Mahraz, Engn Lab Organometall Mol Mat & Environm LIMOME, Fes 30000, Morocco

[2] Ibn Zohr Univ, Fac Sci, Team Organ Chem & Valorizat Nat Subst, Agadir 80060, Morocco

[3] Sidi Mohammed Ben Abdellah Univ, City Innovat, Fes 30000, Morocco

来源：

MOLBANK | 2021年 / 2021卷 / 04期

关键词：

triazole; alpha-amino phosphonic ester; 1,3-dipolar cycloaddition; click chemistry; 1D and 2D NMR; HRMS; CLICK CHEMISTRY; ANTIVIRAL ACTIVITY; COMBINATION; DESIGN;

D O I：

10.3390/M1285

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have previously published new biheterocyclic phospohonic alpha-amino esters of the 1,2,3-triazole-benzimidazole and 1,2,3-triazole-carbazole type. The aim of the present paper was to describe a new phosponic aminoester bearing a triazole ring substituted in position 5 by an ester group. Thus, according to the same catalytic process used previously, the compound naphthalen-2-yl 1-(benzamido(diethoxyphosphoryl)methyl)-1H-1,2,3-triazole-4-carboxylate was synthesized with an excellent yield and high regioselectivity via the copper (I)-catalyzed alkyne-azide cycloaddition reaction (CuAAC), using diethyl (alpha-azido(benzamido)methyl)phosphonate (1) as a dipole and 2- naphthyl propiolate as a dipolarophile (2). The structure of the new compound was fully characterized by 1D (P-31, H-1-, C-13-) and 2D (H-1-H-1 and H-1-, C-13-) NMR spectroscopy, IR, and HRMS.

引用

页数：12

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