Handheld Reflectance Confocal Microscopy to Aid in the Management of Complex Facial Lentigo Maligna

被引:0
作者
Hibler, Brian P. [1 ]
Yelamos, Oriol [1 ,2 ]
Cordova, Miguel [1 ]
Sierra, Heidy [1 ]
Rajadhyaksha, Milind [1 ]
Nehal, Kishwer S. [1 ]
Rossi, Anthony M. [1 ,3 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dermatol Serv, 16 E 60th St,Ste 407, New York, NY 10022 USA
[2] Univ Barcelona, Hosp Clin Barcelona, Dept Dermatol, Barcelona, Spain
[3] Weill Cornell Med Coll, Dept Dermatol, New York, NY USA
来源
CUTIS | 2017年 / 99卷 / 05期
关键词
SKIN-CANCER DIAGNOSIS; MELANOMA IN-SITU; SPAGHETTI TECHNIQUE; SURGICAL MARGINS; VIVO; ACCURACY; RADIOTHERAPY; IMIQUIMOD; OPTIMIZE; MONITOR;
D O I
暂无
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Diagnosis and management of lentigo maligna (LM) and LM melanoma (LMM) is challenging. Novel noninvasive imaging technologies such as reflectance confocal microscopy (RCM) have advanced the ability to better diagnose and monitor challenging lesions. In addition, the new handheld RCM (HRCM) together with the use of videomosaics has allowed an accurate evaluation of large lesions in concave/convex areas of the body (eg, the face). Herein, we review the impact of HRCM in the detection, treatment decisionmaking, and monitoring of 5 cases of complex facial LM/LMM. In the cases presented, HRCM enabled the detection of subclinical margins, presence of invasion, detection of persistence/recurrence, and monitoring of surgical and nonsurgical therapies. In this preliminary report, our results suggest that HRCM is a versatile ancillary tool in pretreatment decision-making, intraoperative surgical mapping, and posttreatment monitoring of complex facial LM/LMM.
引用
收藏
页码:346 / +
页数:8
相关论文
共 28 条
[1]   Histologic evaluation of lentigo maligna with permanent sections: Implications regarding current guidelines [J].
Agarwal-Antal, N ;
Bowen, GM ;
Gerwels, JW .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2002, 47 (05) :743-748
[2]   In vivo reflectance confocal microscopy to monitor the response of lentigo maligna to imiquimod [J].
Alarcon, Ivette ;
Carrera, Cristina ;
Alos, Llucia ;
Palou, Josep ;
Malvehy, Josep ;
Puig, Susana .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2014, 71 (01) :49-55
[3]   Clinical Indications for Use of Reflectance Confocal Microscopy for Skin Cancer Diagnosis [J].
Borsari, Stefania ;
Pampena, Riccardo ;
Lallas, Aimilios ;
Kyrgidis, Athanassios ;
Moscarella, Elvira ;
Benati, Elisa ;
Raucci, Margherita ;
Pellacani, Giovanni ;
Zalaudek, Iris ;
Argenziano, Giuseppe ;
Longo, Caterina .
JAMA DERMATOLOGY, 2016, 152 (10) :1093-1098
[4]   In Vivo Reflectance Confocal Microscopy to Optimize the Spaghetti Technique for Defining Surgical Margins of Lentigo Maligna [J].
Champin, Julie ;
Perrot, Jean-Luc ;
Cinotti, Elisa ;
Labeille, Bruno ;
Douchet, Catherine ;
Parrau, Gregory ;
Cambazard, Frederic ;
Seguin, Pierre ;
Alix, Thomas .
DERMATOLOGIC SURGERY, 2014, 40 (03) :247-256
[5]   Low recurrence rates for in situ and invasive melanomas using Mohs micrographic surgery with melanoma antigen recognized by T cells 1 (MART-1) immunostaining: Tissue processing methodology to optimize pathologic staging and margin assessment [J].
Etzkorn, Jeremy Robert ;
Sobanko, Joseph F. ;
Elenitsas, Rosalie ;
Newman, Jason G. ;
Goldbach, Hayley ;
Shin, Thuzar M. ;
Miller, Christopher J. .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2015, 72 (05) :840-850
[6]   Skin Cancer Diagnosis With Reflectance Confocal Microscopy Reproducibility of Feature Recognition and Accuracy of Diagnosis [J].
Farnetani, Francesca ;
Scope, Alon ;
Braun, Ralph P. ;
Gonzalez, Salvador ;
Guitera, Pascale ;
Malvehy, Josep ;
Manfredini, Marco ;
Marghoob, Ashfaq A. ;
Moscarella, Elvira ;
Oliviero, Margaret ;
Puig, Susana ;
Rabinovitz, Harold S. ;
Stanganelli, Ignazio ;
Longo, Caterina ;
Malagoli, Carlotta ;
Vinceti, Marco ;
Pellacani, Giovanni .
JAMA DERMATOLOGY, 2015, 151 (10) :1075-1080
[7]   Radiotherapy for lentigo maligna: a literature review and recommendations for treatment [J].
Fogarty, G. B. ;
Hong, A. ;
Scolyer, R. A. ;
Lin, E. ;
Haydu, L. ;
Guitera, P. ;
Thompson, J. .
BRITISH JOURNAL OF DERMATOLOGY, 2014, 170 (01) :52-58
[8]   Use of handheld reflectance confocal microscopy for in vivo diagnosis of solitary facial papules: a case series [J].
Fraga-Braghiroli, N. A. ;
Stephens, A. ;
Grossman, D. ;
Rabinovitz, H. ;
Castro, R. P. R. ;
Scope, A. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2014, 28 (07) :933-942
[9]   Upstaging From Melanoma in Situ to Invasive Melanoma on the Head and Neck After Complete Surgical Resection [J].
Gardner, Kevin H. ;
Hill, Dane E. ;
Wright, Adam C. ;
Brewer, Jerry D. ;
Arpey, Christopher J. ;
Otley, Clark C. ;
Roenigk, Randall K. ;
Baum, Christian L. .
DERMATOLOGIC SURGERY, 2015, 41 (10) :1122-1125
[10]   The "spaghetti technique": An alternative to Mohs surgery or staged surgery for problematic lentiginous melanoma (lentigo maligna and acral lentiginous melanoma) [J].
Gaudy-Marqueste, Caroline ;
Perchenet, Anne-Sophie ;
Tasei, Anne-Marie ;
Madjlessi, Nika ;
Magalon, Guy ;
Richard, Marie-Aleth ;
Grob, Jean-Jacques .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2011, 64 (01) :113-118