The effects of pessimism on cell-mediated immunity in rats

被引：7

作者：

Curzytek, Katarzyna ^{[1
]}

Kubera, Marta ^{[1
]}

Trojan, Ewa ^{[1
]}

Wojcik, Kinga ^{[2
]}

Basta-Kaim, Agnieszka ^{[1
]}

Detka, Jan ^{[1
]}

Maes, Michael ^{[3
]}

Rygula, Rafal ^{[4
]}

机构：

[1] Polish Acad Sci, Dept Expt Neuroendocrinol, Inst Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland

[2] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Microbiol, Krakow, Poland

[3] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand

[4] Polish Acad Sci, Inst Pharmacol, Affect Cognit Neurosci Lab, Dept Behav Neurosci & Drug Dev, 12 Smetna St, PL-31343 Krakow, Poland

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2018年 / 80卷

关键词：

Ambiguous-cue interpretation; Pessimism; Optimism; Cognitive judgment bias; Cytokine; Spleen; AMBIGUOUS-CUE INTERPRETATION; GENERALIZED OUTCOME EXPECTANCIES; COGNITIVE JUDGMENT BIAS; INTERPRETATION PARADIGM; BRAIN ASYMMETRY; DISPOSITIONAL OPTIMISM; IL-10; PRODUCTION; BREAST-CANCER; T-CELLS; STRESS;

D O I：

10.1016/j.pnpbp.2017.04.034

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We used a recently developed ambiguous-cue interpretation (ACI) paradigm to investigate whether 'optimism' and 'pessimism' as behavioural traits may be interrelated with immune functions in rodents. To this aim, in a series of ACI tests (cognitive bias screening, CBS), we identified rats that displayed 'pessimistic' and 'optimistic' traits. We found significant differences in immune biomarkers between 'optimistic' and 'pessimistic' animals. Moreover 'pessimism' was associated with significantly lower relative weight of the spleen and thymus, significantly decreased proliferative activity of splenocytes. Pessimism was associated with an increased production of interleukin-(IL)1 beta and IL-4, activin A, L-selectin, interferon (IFN)-gamma and some chemokines and receptors for advanced glycation endproducts. The findings indicate an inflammatory profile in "pessimistic" animals.

引用

页码：295 / 303

页数：9

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