Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats

被引：6

作者：

Sung, Yen-Ling ^{[1
]}

Wu, Chih-En ^{[1
]}

Syu, Jhen-Yang ^{[1
]}

Kuo, Terry B. J. ^{[2
]}

Li, Jai-Yi ^{[3
]}

Chen, Chieh-Wen ^{[4
]}

Weng, Ching-Hui ^{[5
]}

Hsu, Wei-Hsuan ^{[5
]}

Chen, Shih-Ann ^{[5
,6
]}

Hu, Yu-Feng ^{[5
,6
]}

Lin, Shien-Fong ^{[1
]}

机构：

[1] Natl Chiao Tung Univ, Coll Elect & Comp Engn, Inst Biomed Engn, Hsinchu, Taiwan

[2] Taipei Med Univ, Grad Inst Biomed Informat, Taipei, Taiwan

[3] Yuanpei Univ Med Technol, Dept Hlth & Leisure Management, Hsinchu, Taiwan

[4] Natl Yang Ming Univ, Inst Brain Sci, Taipei, Taiwan

[5] Taipei Vet Gen Hosp, Div Cardiol, Dept Med, Taipei, Taiwan

[6] Natl Yang Ming Univ, Sch Med, Fac Med, Taipei, Taiwan

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2018年 / 102卷

关键词：

Spontaneously hypertensive rat; Exercise; Ventricular tachycardia; Heart rate variability; HEART-RATE-VARIABILITY; LEFT-VENTRICULAR HYPERTROPHY; ATRIAL-FIBRILLATION; BLOOD-PRESSURE; CARDIAC-ARRHYTHMIAS; ALTERNANS; RESTITUTION; SYSTEM; ACTIVATION;

D O I：

10.1016/j.compbiomed.2018.08.016

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. The aged SHRs were divided into control and voluntary exercise groups. Ambulatory electrocardiography was recorded for the heart rate variability (HRV) analysis. Programmed stimulation was applied to exposed hearts to induce ventricular arrhythmia in situ. Then, the hearts were isolated for an optical mapping study. The results showed that increased HRV indices were broadly related to vagal dominance in the high-intensity exercise group. Exercise altered the electrical propagation dynamic properties, such as the action potential duration restitution (APDR). Furthermore, the VF inducibility decreased with increased exercise intensity. Taken together, our results suggest that long-term exercise reduces the risk of arrhythmogenesis in aged SHRs through enhanced vagal control and stabilized electrical dynamics.

引用

页码：390 / 395

页数：6