Wild edible onions - Allium flavum and Allium carinatum - successfully prevent adverse effects of chemotherapeutic drug doxorubicin

被引：22

作者：

Aleksandar, Pavic ^{[1
]}

Dragana, Mitic-Culafic ^{[2
]}

Nebojsa, Jasnic ^{[2
]}

Biljana, Nikolic ^{[2
]}

Natasa, Simin ^{[3
]}

Branka, Vasiljevic ^{[1
]}

Jelena, Knezevic-Vukcevic ^{[2
]}

机构：

[1] Univ Belgrade, Inst Mol Genet & Genet Engn, Vojvode Stepe 444a, Belgrade 11000, Serbia

[2] Univ Belgrade, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia

[3] Univ Novi Sad, Fac Sci, Dept Chem Biochem & Environm Protect, Trg Dositeja Obradovica 3, Novi Sad 21000, Serbia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2019年 / 109卷

关键词：

Allium extracts; Doxorubicin; Anticancer activity; Zebrafish embryos; Cardio- and myeloprotection; Anti-angiogenesis; CYTOTOXIC ACTIVITIES; RICH FRACTION; ANGIOGENESIS; ANTIOXIDANT; CANCER; DEXRAZOXANE; INHIBITORS; ZEBRAFISH; PHENOLICS; BEVERAGES;

D O I：

10.1016/j.biopha.2018.11.106

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The objective of this study was to evaluate potential of two chemically characterized edible wild onion species, Allium flavum and Allium carinatum, to reduce side effects of cytostatic doxorubicin (Dox). Since Dox application is mainly limited due to its high cardiotoxicity, while there are no approved cardioprotective agents for the prevention of Dox adverse effects, new co-treatments are urgently needed. Here, we showed that methanol extracts expressed high antioxidant activity and synergistically increased Dox anticancer activity against human hepatoma (HepG2) and lung carcinoma (A549) cells, while protected normal human fibroblasts (MRC-5) from Dox cytotoxicity. Analysis of the antioxidative enzymes level (catalase and superoxide dismutases) showed that the catalase level was differently altered in cancer cells compared to normal cells upon applied treatments. In vivo toxicity evaluation in the zebrafish model revealed significantly lower toxicity of extracts compared to Dox, and no teratogenic effects at applied doses. We found that extracts successfully rescued the Dox-treated embryos of life-threating cardiomyopathy, while at the same time reduced developmental toxicity and neutropenia. Further analysis demonstrated that extracts had higher anti-angiogenic activity than sunitinib or auranofin, clinically used anti-angiogenic drugs. In addition, angiogenesis was markedly more suppressed in Dox-extract cotreatments than upon single treatments.

引用

页码：2482 / 2491

页数：10

共 39 条

[21] Quantitative determination of plant phenolics in Urtica dioica extracts by high-performance liquid chromatography coupled with tandem mass spectrometric detection [J].