Cross-reactive antibodies after SARS-CoV-2 infection and vaccination

被引：1

作者：

Grobben, Marloes ^{[1
]}

van der Straten, Karlijn ^{[1
]}

Brouwer, Philip J. M. ^{[1
]}

Brinkkemper, Mitch ^{[1
]}

Maisonnasse, Pauline ^{[2
]}

Dereuddre-Bosquet, Nathalie ^{[2
]}

Appelman, Brent ^{[1
]}

Lovell, A. H. Ayesha ^{[1
]}

van Vught, Lonneke A. ^{[3
]}

Burger, Judith A. ^{[1
]}

Poniman, Meliawati ^{[1
]}

Oomen, Melissa ^{[1
]}

Eggink, Dirk ^{[4
]}

Bijl, Tom P. L. ^{[1
]}

van Willigen, Hugo D. G. ^{[1
]}

Wynberg, Elke ^{[5
]}

Verkaik, Bas J. ^{[1
]}

Figaroa, Orlane J. A. ^{[1
]}

de Vries, Peter J. ^{[6
]}

Boertien, Tessel M. ^{[6
]}

Bomers, Marije K. ^{[1
]}

Sikkens, Jonne J. ^{[1
]}

Le Grand, Roger ^{[7
]}

de Jong, Menno D. ^{[8
]}

Prins, Maria ^{[2
]}

Chung, Amy W. ^{[9
]}

de Bree, Godelieve J. ^{[1
]}

Sanders, Rogier W. ^{[1
]}

van Gils, Marit J. ^{[1
]}

机构：

[1] Amsterdam UMC, Amsterdam, Netherlands

[2] Ctr Immunol Viral Autoimmune Hematol & Bacterial, Fontenay Aux Roses, France

[3] AMC, Ctr Expt Mol Med, Amsterdam, Netherlands

[4] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[5] Publ Hlth Serv Amsterdam GGD, Amsterdam, Netherlands

[6] Tergooi Hosp, Amsterdam, Netherlands

[7] Univ Paris, Paris, France

[8] Amsterdam Univ Med Ctr, Dept Med Microbiol & Infect Prevent, Amsterdam, Netherlands

[9] Univ Melbourne, Melbourne, Vic, Australia

来源：

ELIFE | 2021年 / 10卷

基金：

英国医学研究理事会;

关键词：

antibodies; SARS-CoV-2; coronavirus; cross-reactivity; vaccine; COVID-19; Human; Other; SPIKE; CORONAVIRUSES; RESPONSES;

D O I：

10.7554/eLife.70330; 10.7554/eLife.70330.sa0; 10.7554/eLife.70330.sa1; 10.7554/eLife.70330.sa2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not protect against future novel coronavirus outbreaks, emphasizing the need for more broadly protective vaccines. To inform the development of a pan-coronavirus vaccine, we investigated the presence and specificity of cross-reactive antibodies against the spike (S) proteins of human coronaviruses (hCoV) after SARS-CoV-2 infection and vaccination. We found an 11- to 123-fold increase in antibodies binding to SARS-CoV and MERS-CoV as well as a 2- to 4-fold difference in antibodies binding to seasonal hCoVs in COVID-19 convalescent sera compared to pre-pandemic healthy donors, with the S2 subdomain of the S protein being the main target for cross-reactivity. In addition, we detected cross-reactive antibodies to all hCoV S proteins after SARS-CoV-2 vaccination in macaques and humans, with higher responses for hCoV more closely related to SARS-CoV-2. These findings support the feasibility of and provide guidance for development of a pan-coronavirus vaccine.

引用

页数：19

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