Genetic variation in insulin/IGF-1 signaling pathways and longevity

被引：68

作者：

Ziv, Elad ^{[1
]}

Hu, Donglei

机构：

[1] Univ Calif San Francisco, Dept Med, Inst Human Genet, San Francisco, CA 94143 USA

来源：

AGEING RESEARCH REVIEWS | 2011年 / 10卷 / 02期

关键词：

Genetics; Single nucleotide polymorphisms; Insulin; Insulin-like growth factor 1; Longevity; Association studies; LIFE-SPAN; CAENORHABDITIS-ELEGANS; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; I RECEPTOR; C-ELEGANS; FOXO3A; ASSOCIATION; DAF-16; DROSOPHILA;

D O I：

10.1016/j.arr.2010.09.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The insulin/IGF-1 pathway has been shown to affect lifespan and rate of aging in a variety of animals including worms, flies and mice. Genetic variation in this pathway may also affect human longevity. We review the evidence for the effect of this pathway on longevity with a focus on the genetic studies in humans to date. One gene, FOXO3A, a transcriptional factor homologous to daf-16, has been repeatedly associated with increased lifespan in several studies in different ethnic populations. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：201 / 204

页数：4

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