Immune roles of dendritic cells in stem cell transplantation

被引：4

作者：

Zhang, Cheng ^{[1
]}

Liao, Wenwei ^{[1
]}

Liu, Furong ^{[1
]}

Zhu, Xiaofeng ^{[1
]}

He, Xiaoshun ^{[1
]}

Hu, Anbin ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China

来源：

CLINICAL TRANSPLANTATION | 2017年 / 31卷 / 11期

基金：

中国国家自然科学基金;

关键词：

antitumor immunity; dendritic cell; immune tolerance; stem cell; transplantation; GRAFT-VERSUS-HOST; REGULATORY T-CELLS; LEUKEMIA ACTIVITY; TOLERANCE; DISEASE; GVHD; DERIVATIVES; IMMUNOGENICITY; ALLOREACTIVITY; INDUCTION;

D O I：

10.1111/ctr.13090

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Dendritic cells (DCs) are professional antigen-presenting cells and initial stimulators for immune response. DCs can shape their functions based on their immune states, which are crucial for the balance of immunity and tolerance to preserve homeostasis. In the immune response involved in stem cell transplantation, DCs also play important roles in inducing immune tolerance and antitumor immunity. After the rapid development of stem cell transplantation technology in recent years, the risks of graft rejection, tumor recurrence, and tumorigenicity are still present after stem cell transplantation. It is important to understand the mechanisms of DC-mediated immune tolerance and stimulation during stem cell transplantation. In this review, we will summarize and analyze the regulatory mechanisms of DCs in stem cell transplantation and their application in clinical settings. It may help to promote the innovation in basic theories and therapeutic approaches of stem cell transplantation.

引用

页数：5

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