Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

被引：301

作者：

Rabbani, Naila ^{[1
]}

Thornalley, Paul J. ^{[1
]}

机构：

[1] Univ Warwick, Univ Hosp, Warwick Med Sch, Clin Sci Res Labs, Coventry CV2 2DX, W Midlands, England

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 458卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Glycation; Oxidative stress; Hypoxia; Inflammation; Diabetes; Cardiovascular disease; GLYOXALASE; 1; OXIDATIVE STRESS; COPY NUMBER; METHYLGLYOXAL; GLYCATION; PRODUCTS; ACCUMULATION; NITRATION; ARGININE; SYSTEM;

D O I：

10.1016/j.bbrc.2015.01.140

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license

引用

页码：221 / 226

页数：6

共 50 条

[1] Accumulation of α-oxoaldehydes during oxidative stress:: A role in cytotoxicity [J].

Abordo, EA ;

Minhas, HS ;

Thornalley, PJ .

BIOCHEMICAL PHARMACOLOGY, 1999, 58 (04) :641-648

[2] The Proinflammatory Cytokine High-Mobility Group Box-1 Mediates Retinal Neuropathy Induced by Diabetes [J].

Abu El-Asrar, Ahmed M. ;

Siddiquei, Mohammad Mairaj ;

Nawaz, Mohd Imtiaz ;

Geboes, Karel ;

Mohammad, Ghulam .

MEDIATORS OF INFLAMMATION, 2014, 2014

[3] Profound mishandling of protein glycation degradation products in uremia and dialysis [J].

Agalou, S ;

Ahmed, N ;

Babaei-Jadidi, R ;

Dawnay, A ;

Thornalley, PJ .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (05) :1471-1485

[4] Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteins [J].

Ahmed, N ;

Thornalley, PJ ;

Dawczynski, J ;

Franke, S ;

Strobel, J ;

Stein, G ;

Haik, GM .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (12) :5287-5292

[5] Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment [J].

Ahmed, N ;

Ahmed, U ;

Thornalley, PJ ;

Hager, K ;

Fleischer, G ;

Münch, G .

JOURNAL OF NEUROCHEMISTRY, 2005, 92 (02) :255-263

[6]

[Anonymous], 1994, BIOCH PHARM, DOI DOI 10.1016/0006-2952(94)90035-3

[7] Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia [J].

Arai, Makoto ;

Yuzawa, Hiroko ;

Nohara, Izumi ;

Ohnishi, Tetsuo ;

Obata, Nanako ;

Iwayama, Yoshimi ;

Haga, Seiichi ;

Toyota, Tomoko ;

Ujike, Hiroshi ;

Arai, Mayumi ;

Ichikawa, Tomoe ;

Nishida, Atsushi ;

Tanaka, Yoko ;

Furukawa, Aizo ;

Aikawa, Yuuzou ;

Kuroda, Osamu ;

Niizato, Kazuhiro ;

Izawa, Ryosuke ;

Nakamura, Kazuhiko ;

Mori, Norio ;

Matsuzawa, Daisuke ;

Hashimoto, Kenji ;

Iyo, Masaomi ;

Sora, Ichiro ;

Matsushita, Masaaki ;

Okazaki, Yuji ;

Yoshikawa, Takeo ;

Miyata, Toshio ;

Itokawa, Masanari .

ARCHIVES OF GENERAL PSYCHIATRY, 2010, 67 (06) :589-597

[8] Quantitative measurement of specific biomarkers for protein oxidation, nitration and glycation in Arabidopsis leaves [J].

Bechtold, Ulrike ;

Rabbani, Naila ;

Mullineaux, Philip M. ;

Thornalley, Paul J. .

PLANT JOURNAL, 2009, 59 (04) :661-671

[9] Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology [J].

Berner, A. K. ;

Brouwers, O. ;

Pringle, R. ;

Klaassen, I. ;

Colhoun, L. ;

McVicar, C. ;

Brockbank, S. ;

Curry, J. W. ;

Miyata, T. ;

Brownlee, M. ;

Schlingemann, R. O. ;

Schalkwijk, C. ;

Stitt, A. W. .

DIABETOLOGIA, 2012, 55 (03) :845-854

[10] Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy [J].

Bierhaus, Angelika ;

Fleming, Thomas ;

Stoyanov, Stoyan ;

Leffler, Andreas ;

Babes, Alexandru ;

Neacsu, Cristian ;

Sauer, Susanne K. ;

Eberhardt, Mirjam ;

Schnoelzer, Martina ;

Lasischka, Felix ;

Neuhuber, Winfried L. ;

Kichko, Tatjana I. ;

Konrade, Ilze ;

Elvert, Ralf ;

Mier, Walter ;

Pirags, Valdis ;

Lukic, Ivan K. ;

Morcos, Michael ;

Dehmer, Thomas ;

Rabbani, Naila ;

Thornalley, Paul J. ;

Edelstein, Diane ;

Nau, Carla ;

Forbes, Josephine ;

Humpert, Per M. ;

Schwaninger, Markus ;

Ziegler, Dan ;

Stern, David M. ;

Cooper, Mark E. ;

Haberkorn, Uwe ;

Brownlee, Michael ;

Reeh, Peter W. ;

Nawroth, Peter P. .

NATURE MEDICINE, 2012, 18 (06) :926-+

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