Functional Role for Transporter Isoforms in Optimizing Membrane Transport

被引：3

作者：

Berezhkovskii, Alexander M. ^{[2
]}

Lizunov, Vladimir A. ^{[1
]}

Zimmerberg, Joshua ^{[1
]}

Bezrukov, Sergey M. ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Phys Biol, NIH, Bethesda, MD USA

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Math & Stat Comp Lab, Div Computat Biosci, Ctr Informat Technol,NIH, Bethesda, MD USA

来源：

BIOPHYSICAL JOURNAL | 2011年 / 101卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CHANNELS; BINDING;

D O I：

10.1016/j.bpj.2011.06.004

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Quantitative analysis of carrier parameters demonstrates that with decreasing substrate concentration the optimal strength of substrate-carrier interaction which maximizes the flux across the membrane increases and requires less fine-tuning than at higher concentrations of the substrate.

引用

页码：L14 / L16

页数：3

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