Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice

被引：26
作者：
Brinks, V. [1 ]
de Kloet, E. R. [1 ]
Oitzl, M. S. [1 ]
机构：
[1] Leiden Univ, LUMC, LACDR, Div Med Pharmacol,Gorlaeus Labs, NL-2300 RA Leiden, Netherlands
来源：
STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES | 2007年 / 167卷
关键词：
PTSD; fear conditioning; C57BL/6J and BALB/c mice; stress system;
D O I：
10.1016/S0079-6123(07)67019-8
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Pavlovian fear conditioning in rodents allows studying the formation and extinction of fear memories. Male C57BL/6J but not BALB/c mice showed differential fear memory performance expressed as freezing and scanning behaviour for context and cue. Glucocorticoid stress hormones modulate the processing of fear-related stimuli. The augmented corticosterone response of BALB/c mice to conditioning and testing, therefore, might have contributed to the strain-dependent formation of fear memories. We propose that modulation of extinction processes by glucocorticoids can be relevant in modelling anxiety disorders.
引用
收藏
页码：257 / 261
页数：5
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