Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice

被引：26

作者：

Brinks, V. ^{[1
]}

de Kloet, E. R. ^{[1
]}

Oitzl, M. S. ^{[1
]}

机构：

[1] Leiden Univ, LUMC, LACDR, Div Med Pharmacol,Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

来源：

STRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES | 2007年 / 167卷

关键词：

PTSD; fear conditioning; C57BL/6J and BALB/c mice; stress system;

D O I：

10.1016/S0079-6123(07)67019-8

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Pavlovian fear conditioning in rodents allows studying the formation and extinction of fear memories. Male C57BL/6J but not BALB/c mice showed differential fear memory performance expressed as freezing and scanning behaviour for context and cue. Glucocorticoid stress hormones modulate the processing of fear-related stimuli. The augmented corticosterone response of BALB/c mice to conditioning and testing, therefore, might have contributed to the strain-dependent formation of fear memories. We propose that modulation of extinction processes by glucocorticoids can be relevant in modelling anxiety disorders.

引用

页码：257 / 261

页数：5

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