Dampening insulin signaling by an NLRP3 'meta-flammasome'

被引：28

作者：

Choi, Augustine M. K. ^{[1
]}

Nakahira, Kiichi ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 05期

关键词：

INFLAMMASOME; ACTIVATION;

D O I：

10.1038/ni.2028

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inflammasome has been linked to metabolic disorders such as obesity and type 2 diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy critically mediates cytoplasmic receptor NLRP3-dependent activation of the inflammasome by the saturated fatty acids contained in a high-fat diet.

引用

页码：379 / 380

页数：3

共 12 条

[1] Inflammation and metabolic disorders [J].

Hotamisligil, Goekhan S. .

NATURE, 2006, 444 (7121) :860-867

[2] Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [J].

Lamkanfi, Mohamed ;

Mueller, James L. ;

Vitari, Alberto C. ;

Misaghi, Shahram ;

Fedorova, Anna ;

Deshayes, Kurt ;

Lee, Wyne P. ;

Hoffman, Hal M. ;

Dixit, Vishva M. .

JOURNAL OF CELL BIOLOGY, 2009, 187 (01) :61-70

[3] Interleukin-1-receptor antagonist in type 2 diabetes mellitus [J].

Larsen, Claus M. ;

Faulenbach, Mirjam ;

Vaag, Allan ;

Volund, Aage ;

Ehses, Jan A. ;

Seifert, Burkhardt ;

Mandrup-Poulsen, Thomas ;

Donath, Marc Y. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (15) :1517-1526

[4] Autophagy in immunity and inflammation [J].

Levine, Beth ;

Mizushima, Noboru ;

Virgin, Herbert W. .

NATURE, 2011, 469 (7330) :323-335

[5] Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes [J].

Masters, Seth L. ;

Dunne, Aisling ;

Subramanian, Shoba L. ;

Hull, Rebecca L. ;

Tannahill, Gillian M. ;

Sharp, Fiona A. ;

Becker, Christine ;

Franchi, Luigi ;

Yoshihara, Eiji ;

Chen, Zhe ;

Mullooly, Niamh ;

Mielke, Lisa A. ;

Harris, James ;

Coll, Rebecca C. ;

Mills, Kingston H. G. ;

Mok, K. Hun ;

Newsholme, Philip ;

Nunez, Gabriel ;

Yodoi, Junji ;

Kahn, Steven E. ;

Lavelle, Ed C. ;

O'Neill, Luke A. J. .

NATURE IMMUNOLOGY, 2010, 11 (10) :897-U1501

[6] Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome [J].

Nakahira, Kiichi ;

Haspel, Jeffrey Adam ;

Rathinam, Vijay A. K. ;

Lee, Seon-Jin ;

Dolinay, Tamas ;

Lam, Hilaire C. ;

Englert, Joshua A. ;

Rabinovitch, Marlene ;

Cernadas, Manuela ;

Kim, Hong Pyo ;

Fitzgerald, Katherine A. ;

Ryter, Stefan W. ;

Choi, Augustine M. K. .

NATURE IMMUNOLOGY, 2011, 12 (03) :222-U57

[7] The Inflammasomes [J].

Schroder, Kate ;

Tschopp, Jurg .

CELL, 2010, 140 (06) :821-832

[8] The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin [J].

Shaw, RJ ;

Lamia, KA ;

Vasquez, D ;

Koo, SH ;

Bardeesy, N ;

DePinho, RA ;

Montminy, M ;

Cantley, LC .

SCIENCE, 2005, 310 (5754) :1642-1646

[9] The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity [J].

Stienstra, Rinke ;

Joosten, Leo A. B. ;

Koenen, Tim ;

van Tits, Berry ;

van Diepen, Janna A. ;

van den Berg, Sjoerd A. A. ;

Rensen, Patrick C. N. ;

Voshol, Peter J. ;

Fantuzzi, Giamilla ;

Hijmans, Anneke ;

Kersten, Sander ;

Muller, Michael ;

van den Berg, Wim B. ;

van Rooijen, Nico ;

Wabitsch, Martin ;

Kullberg, Bart-Jan ;

van der Meer, Jos W. M. ;

Kanneganti, Thirumala ;

Tack, Cees J. ;

Netea, Mihai G. .

CELL METABOLISM, 2010, 12 (06) :593-605

[10] The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance [J].

Vandanmagsar, Bolormaa ;

Youm, Yun-Hee ;

Ravussin, Anthony ;

Galgani, Jose E. ;

Stadler, Krisztian ;

Mynatt, Randall L. ;

Ravussin, Eric ;

Stephens, Jacqueline M. ;

Dixit, Vishwa Deep .

NATURE MEDICINE, 2011, 17 (02) :179-U214

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