Dampening insulin signaling by an NLRP3 'meta-flammasome'

被引：28
作者：
Choi, Augustine M. K. [1 ]
Nakahira, Kiichi [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA
来源：
NATURE IMMUNOLOGY | 2011年 / 12卷 / 05期
关键词：
INFLAMMASOME; ACTIVATION;
D O I：
10.1038/ni.2028
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The inflammasome has been linked to metabolic disorders such as obesity and type 2 diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy critically mediates cytoplasmic receptor NLRP3-dependent activation of the inflammasome by the saturated fatty acids contained in a high-fat diet.
引用
收藏
页码：379 / 380
页数：3
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