SiRNA Nanotherapeutics _ The Panacea of Diseases?

被引：4

作者：

Badrealam, Khan Farheen ^{[1
]}

Zubair, Swaleha ^{[2
]}

Owais, Mohammad ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Aligarh, Uttar Pradesh, India

[2] Aligarh Muslim Univ, Womens Coll, Aligarh, Uttar Pradesh, India

来源：

CURRENT GENE THERAPY | 2015年 / 15卷 / 02期

关键词：

Anti-gene; efficacious; RNAi; safe; therapeutic; ZINC-FINGER NUCLEASES; SHORT INTERFERING RNA; DOUBLE-STRANDED-RNA; ONE-STEP GENERATION; CHEMICAL-MODIFICATION; NONVIRAL DELIVERY; GENE; CELLS; SEQUENCE; DNA;

D O I：

10.2174/1566523215666150122130047

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

RNAi based therapeutics hold s great promises to be an efficient strategy of the anti-gene realm in context of its therapeutic applications; however, despite significant potentials, its full efficacy cannot be realized in real sense owing to various confronts that plague its advancement. Efforts need to be driven for the development of specific and efficacious strategies to subdue some of their crucial constraints towards successes in clinics. This article will present the major impediments that encumber successful translation of siRNA concept into reality and the ongoing research endeavours to get through those stumbling blocks along with their inadequacies.

引用

页码：201 / 214

页数：14

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