A new linker for primary amines applicable to combinatorial approaches.

被引：26

作者：

Bannwarth, W

Huebscher, J

Barner, R

机构：

[1] PRPC, F. Hoffmann-La Roche Ltd.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(96)00258-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe a new linker molecule (ADCC-linker) for the attachment of primary amines to solid support. The linker is stable towards acidic conditions (eg.TFA) basic conditions (eg.piperidine, DBU) as well as towards uronium type coupling reagents. The amine can be quantitatively released from the support using a 2% hydrazine in DMF solution. Copyright (C) 1996 Elsevier Science Ltd

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页码：1525 / 1528

页数：4

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