Advances in research on pharmacotherapy of sarcopenia

被引：41

作者：

Yang, Feike ^{[1
,2
]}

Liu, Zhijie ^{[1
]}

Chen, Wei ^{[1
]}

机构：

[1] Cent Hosp Changsha City, Dept Geriatr Med, Changsha, Peoples R China

[2] Cent Hosp Changsha City, Dept Geriatr Med, Changsha 410004, Hunan, Peoples R China

来源：

AGING MEDICINE | 2021年 / 4卷 / 03期

关键词：

aging; muscle wasting; pathogenesis; pharmacotherapy; sarcopenia; signaling; ANDROGEN RECEPTOR MODULATOR; FOLLISTATIN GENE-THERAPY; SKELETAL-MUSCLE MASS; DOUBLE-BLIND; TESTOSTERONE REPLACEMENT; TRANSDERMAL TESTOSTERONE; AROMATASE INHIBITOR; PHYSICAL FUNCTION; GROWTH-HORMONE; II RECEPTORS;

D O I：

10.1002/agm2.12168

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Sarcopenia is a comprehensive degenerative disease with the progressive loss of skeletal muscle mass with age, accompanied by the loss of muscle strength and muscle dysfunction. As a new type of senile syndrome, sarcopenia seriously threatens the health of the elderly. The first-line treatment for sarcopenia is exercise and nutritional supplements. However, pharmacotherapy will provide more reliable and sustainable interventions in geriatric medicine. Clinical trials of new drugs targeting multiple molecules are ongoing. This article focuses on the latest progress in pharmacotherapeutic approaches of sarcopenia in recent years by comprehensively reviewing the clinical outcomes of the existing and emerging pharmacotherapies as well as the molecular mechanisms underlying their therapeutic benefits and side effects. Signaling of the pharmacotherapies of sarcopenia. image

引用

页码：221 / 233

页数：13

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