Endothelial progenitor cells accelerate the resolution of deep vein thrombosis

被引：65
作者：
Li, Wen-Dong [1 ]
Li, Xiao-Qiang [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 2, Dept Vasc Surg, 1055 Sanxiang Rd, Suzhou 215000, Jiangsu, Peoples R China
来源：
VASCULAR PHARMACOLOGY | 2016年 / 83卷
基金：
中国国家自然科学基金;
关键词：
Endothelial progenitor cells; Thrombosis; Revascularization; TISSUE-PLASMINOGEN-ACTIVATOR; NITRIC-OXIDE SYNTHASE; PERCUTANEOUS CORONARY INTERVENTION; FIBROBLAST-GROWTH-FACTOR; BONE-MARROW; IN-VITRO; VENOUS THROMBOSIS; VASCULAR REPAIR; STEM-CELLS; THERAPEUTIC NEOVASCULARIZATION;
D O I：
10.1016/j.vph.2015.07.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Deep vein thrombosis (DVT) causes high morbidity and mortality. Successful resolution of DVT-related thrombi is the key point in the treatment of DVT. Recently, endothelial progenitor cells (EPCs) which are multipotent progenitor cells mainly residing in human bone marrow have emerged as a promising therapeutic choice for DVT-related thrombus resolution. In this review, we discussed the mobilization and homing property of EPCs into the sites of thrombosis, mechanisms of EPCs in DVT-related thrombus resolution from the aspects of promoting endothelial regeneration, revascularization, vasoactive and angiogenic factor secretion, proteinase generation, thrombus propagation and recurrence prevention, and vein wall remodeling. In addition, we also provide suggestions on EPCs as a therapeutic choice for thrombus resolution. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：10 / 16
页数：7
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